Brian Hull as Count "Drac" Dracula, the founder of Hotel Transylvania and Mavis' father, Johnny's father-in-law, Vlad's son, and Dennis' maternal grandfather. He was originally voiced by Adam Sandler in the first three films.
Andy Samberg as Johnathan "Johnny" Loughran, Mavis' husband, Drac’s son-in-law, and Dennis' father.
Selena Gomez as Mavis Dracula, Johnny's wife, Drac’s daughter and Dennis' mother.
Brad Abrell as Frankenstein, Eunice's husband. He was originally voiced by Kevin James in the first three films.
Asher Blinkoff as Dennis, Mavis and Johnny’s son, and Drac’s grandson.
Zoe Berri as Winnie, a werewolf who is the daughter of Wayne and Wanda and a friend of Dennis. She was originally voiced by Sadie Sandler in the first three films.
Asher Bishop as Wesley, a werewolf who is the son of Wayne and Wanda.