Carboplatin

Carboplatin is a drug used in chemotherapy. It is one of a group of related drugs called platins, which have a central platinum atom surrounded by four or six ligands. Carboplatin was invented to be a less toxic alternative to cisplatin.

Structure

Like all platins, carboplatin is a platinum coordination complex. Instead of the two chloride ions that are ligands in cisplatin, carboplatin has one 1,1-cyclobutane dicarboxylate (CBDCA) ligand connected to the atom at two different places. This ligand is harder to separate from the platinum atom than the chlorine atoms in cisplatin.

Preparation

Carboplatin can be made from cisplatin or its chemical precursor, cis-diamminodiiodoplatinum, and a salt of 1,1-cyclobutane dicarboxylate.^[source?]

References

↑ Lebwohl, D.; Canetta, R. (1998). "Clinical development of platinum complexes in cancer therapy: An historical perspective and an update". European Journal of Cancer. 34 (10): 1522–1534. doi:10.1016/S0959-8049(98)00224-X. PMID 9893623.
↑ Ciancetta, Antonella; Coletti, Cecilia; Marrone, Alessandro; Re, Nazzareno (2011). "Activation of carboplatin by chloride ions: A theoretical investigation". Theoretical Chemistry Accounts. 129 (6): 757–769. doi:10.1007/s00214-011-0933-9.

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[1] Lebwohl, D.; Canetta, R. (1998). "Clinical development of platinum complexes in cancer therapy: An historical perspective and an update". European Journal of Cancer. 34 (10): 1522–1534. doi:10.1016/S0959-8049(98)00224-X. PMID 9893623.

[2] Ciancetta, Antonella; Coletti, Cecilia; Marrone, Alessandro; Re, Nazzareno (2011). "Activation of carboplatin by chloride ions: A theoretical investigation". Theoretical Chemistry Accounts. 129 (6): 757–769. doi:10.1007/s00214-011-0933-9.