Click chemistry

In chemical synthesis, click chemistry is a rank of biocompatible small molecule reactions. It is mainly used in bioconjugation. Click chemistry is not a single specific reaction. Click reactions join a biomolecule and a reporter molecule.

The term "click chemistry" was created by K. Barry Sharpless in 1998, and was first fully described by Sharpless, Hartmuth C. Kolb, and M.G. Finn of The Scripps Research Institute in 2001. In 2022, the Nobel Prize in Chemistry was given to Carolyn Bertozzi, Morten P. Meldal and K. Barry Sharpless for their works to click chemistry.

References

  1. ↑ H. C. Kolb; M. G. Finn; K. B. Sharpless (2001). "Click Chemistry: Diverse Chemical Function from a Few Good Reactions". Angewandte Chemie International Edition. 40 (11): 2004–2021. doi:10.1002/1521-3773(20010601)40:11<2004::AID-ANIE2004>3.0.CO;2-5. PMID 11433435.
  2. ↑ R. A. Evans (2007). "The Rise of Azide–Alkyne 1,3-Dipolar 'Click' Cycloaddition and its Application to Polymer Science and Surface Modification". Australian Journal of Chemistry. 60 (6): 384–395. doi:10.1071/CH06457.
  3. ↑ "The Nobel Prize in Chemistry 2022". NobelPrize.org. Retrieved 2022-10-05.