Ghirlandaio is the surname of a family of the Renaissance Italian painters:
- Domenico Ghirlandaio (1449–1494), Michelangelo's teacher
- Davide Ghirlandaio (1452–1525), younger brother of Domenico
- Benedetto Ghirlandaio (1458–1497), younger brother of Domenico and Davide
- Ridolfo Ghirlandaio (1483–1561), son of Domenico
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