Horacio Serpa Uribe (January 4, 1943 – October 31, 2020) was an Colombian politician. He was governor of Santander between January 2008 to December 2011 and candidate in the 1998, 2002, and 2006 presidential elections. He also served in the Senate of Colombia from 2014 to 2018.
Serpa died on 31 October 2020 in Bucaramanga from colon and pancreatic cancer at the age of 77.