Muhammad
(Islamic prophet and messenger) | | Khadijah bint Khuwaylid |
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| | Fatimah | | | | | | | | | | Ali
(1st Imam in Shia) (Rashidun Caliph in Sunni) |
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| Muhsin ibn Ali | | Hasan ibn Ali
(Sunni Rashidun Caliph)
(Imam in Twelver/Zaidi and Musta'li Shia) | | | Husayn ibn Ali
(Imam in Twelver/Zaidi and Musta'li/Nizari Shia) | | | Umm Kulthum bint Ali | | Zaynab bint Ali |
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| | | | Shahrbanu | | Rubab bint Imra al-Qais | | | | Layla bint Abi Murrah al-Thaqafi | | | Umm Ishaq bint Talhah | | | | | | | | | | |
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| | Fatima Sughra | | Sakinah bint Husayn | | Ali al-Asghar ibn Husayn | | Sukayna bint Husayn | | Ali al-Akbar ibn Husayn | | Fatimah bint Husayn | | | |
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| Mother of ‘Umar | | | | Ali ibn Husayn Zayn al-Abidin
4th Twelver/Zaidi and 3rd Musta'li/Nizari Imam | | Fatimah bint Hasan | | Jayda al-Sindhi | | | | | | Ali al-Akbar ibn Husayn | | | |
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| ‘Umar al-Ashraf | | | | | | Muhammad al-Baqir
5th Twelver and 4th Musta'li/Nizari Imam | | Umm Farwah bint al-Qasim
(Umm Farwa) | | Zayd ibn Ali
5th Zaidi Imam | | | Ali al-Asghar ibn Husayn | | | |
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| ‘Alī | | Hamidah Khatun | | | | Ja'far al-Sadiq
6th Twelver and 5th Musta'li/Nizari Imam | | | | Fatima bint al-Hussain'l-Athram ibn al-Hasan ibn Ali | | | Zaynab bint Husayn | | | |
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| al-Ḥasan | | Musa al-Kadhim
7th Twelver Imam | | | Abdullah al-Aftah | | | Isma'il ibn Ja'far
6th Musta'li/Nizari Imam | | Unknown | | Umm Kulthum bint Husayn |
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| ‘Alī | | | | | Ummul Banīn Najmah | | | | | | | | | |
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| al-Nāṣir al-Kabīr | | Ali al-Ridha
8th Twelver Imam | | Sabīkah a.k.a. Khayzurān | | | | | Muhammad ibn Isma'il
7th Sevener/Musta'li/Nizari Imam | | Fatima |
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| | | | Sumānah | | Muhammad al-Jawad
9th Twelver Imam | | | Unknown | | Ahmad al-Wafi
8th Musta'li/Nizari Imam | | Other issue |
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| | | | Ali al-Hadi
10th Twelver Imam | | Hâdise (Hadīthah) / Suzan (Sūsan) / Sevil (Savīl) | | Other issue | | Muhammad at-Taqi
9th Musta'li/Nizari Imam | | Unknown |
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11th Twelver Imam | | Narjis | | | | | | Radi Abdullah
10th Musta'li/Nizari Imam |
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| | | | | | | | Muhammad al-Mahdi
12th Twelver Imam |
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