Marge Simpson (née Bouvier), the mother, a housewife, who is very tolerant (understanding) of her family.
Bart Simpson, the 10-year-old son, who gets in trouble.
Lisa Simpson, the 8-year-old daughter, who is very smart.
Maggie Simpson, the baby girl, who can not talk. She talks once and never speaks again. She is always doing mischief.
"Grampa" Abe Simpson, the father of Homer Simpson. He lives in an old folk's home.
Patty and Selma, Marge's sisters, who have rough voices and often smoke cigarettes. Note that in one episode, Patty is revealed to be a lesbian. Selma has been married several times.
Mona Simpson, the deceased mother of Homer Simpson; wife of Abe Simpson.
Ned Flanders, the Simpsons' religiousdevout neighbor he has two shy children and his wife Maude died in season 11.
Rod and Todd Flanders, Ned's children.
Maude, Ned's dead wife.
Kang and Kodos, two aliens that appear in every Treehouse of Horror their other sibling roger doesn't appear in any other Treehouse of Horror except the first.
Apu Nahasapeemapetilon, convenience store owner his wife is Manjula he has eight infant children. There have been protests that he is a raciststereotype of South Asian people.
Martin Prince, he is the bully's target besides Milhouse and he is also very smart.
Itchy and Scratchy, cartoon cat and mouse who are a different more violent version of Tom and Jerry.
Jimbo Jones, leader of the bullies when Nelson is not around and strongest of the bullies.
Snake (Jailbird), robber and criminal.
Old Gil Gunderson, a salesman who has bad luck.
Sideshow Bob (Robert Terwilliger), was Krusty the Clown's assistant before he was jailed after framing Krusty for armed robbery.
He was married to Selma once, has tried to kill Bart several times, and has gone to prison.
Fat Tony, the town's chief gangster who has a group of mobsters, including Legs and Louie, and occasionally Icepick and Johnny Tightlips. He died in Season 22 and was replaced by his slimmer cousin.
Sideshow Cecil (Cecil Terwilliger), Sideshow Bob's somewhat evil brother, who was also once a clown.
Janey, Lisa's best friend.
Rainier Wolfcastle, The Arnold Schwarzenegger-like Hollywood action hero of Springfield who is in a lot of movies in Springfield.
Mr. Largo, the Springfield Elementary music teacher.
Tobias, the stereotypical Australian boy telephoned by Bart in the episode "Bart vs. Australia".
Superintendent Chalmers, The superintendent of all Springfield elementary schools who does not like Principal Skinner.
Agnes Skinner, The mean mother of Principal Skinner.
Mrs. Krabappel and Ms. Hoover, Bart and Lisa's teachers, who both do not want to teach because they do not have relationships.
Cletus, the hillbilly of Springfield, has a wife named Brandine and have about 30 children.
Hans Moleman, a man who drinks and says he's only 31 years old, while he looks old.
Sideshow Mel, Krusty's second assistant who replaced Bob after going to prison for trying to frame Krusty for armed robbery. He does not say much on the Krusty show (talks with a whistle) and once tried to get gum out of his hair with a bone ....it just made matters worse.