Little Sioux is a city in Iowa in the United States. The Lewis and Clark expedition went through the area in 1804, and named it Little Sioux River. The first European settlers arrived in the 1850s.
The first post office in Little Sioux opened in July, 1857. This was the same year that the first school opened. A two storey brick school was in use by 1885.
In 2008, a boy scout camp near Little Sioux was hit by a tornado. Four boys were killed, and another 48 were injured.