| Route information | ||||
|---|---|---|---|---|
| Length | 120.81 mi (194.42 km) | |||
| Existed | 1922–present | |||
| Major junctions | ||||
| South end | ||||
| North end | ||||
| Location | ||||
| Country | United States | |||
| State | Missouri | |||
| Highway system | ||||
| ||||
Route 51 is a highway in southeastern Missouri. It goes from Illinois Route 150 at the Illinois state line near Chester, Illinois, to Arkansas Highway 139 at the Arkansas state line near Piggott, Arkansas. It is 120.81 miles (194.42 km) long.