Myelofibrosis

Primary myelofibrosis is a relatively rare bone marrow / blood cancer. It is currently classified as a myeloproliferative neoplasm.

Signs and symptoms

Symptoms include:

• Abdominal fullness related to an enlarged spleen (splenomegaly).
• Bone pain
• Bruising and easy bleeding due to inadequate numbers of platelets
• Cachexia (loss of appetite, weight loss, and fatigue)
• Enlargement of both the liver and spleen
• Fatigue
• Gout and high uric acid levels
• Increased susceptibility to infection, such as pneumonia
• Pallor and shortness of breath due to anemia
• In rarer cases, a raised red blood cell volume
• Cutaneous myelofibrosis is a rare skin condition characterized by dermal and subcutaneous nodules.^: 746

References

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