The movie is about Elisabeth Sparkle (Moore), a celebrity who is losing popularity being fired by her producer (Quaid) because of her age. She then uses a black market drug that creates a younger version of herself (Qualley) with sudden side effects.
The Substance premiered at the 77thCannes Film Festival on May 19, 2024, where it was nominated for the Palme d'Or. The movie was theatrically released in the United Kingdom and the United States on September 20, 2024 to positive reviews.
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Mubi in North America, the United Kingdom, Ireland, Germany, Austria, Latin America, Benelux, Turkey, and India; Metropolitan Filmexport in France; and various other distributors in Italy, Spain, Scandinavia, South Korea, Hong Kong, Ukraine, the Baltics, Taiwan, Australia and New Zealand, Poland, Greece, Bulgaria, Romania, former Yugoslavia, and the Commonwealth of Independent States.