Dipeptidylpeptidas-4

DPP4 och inkretiner.

Dipeptidylpeptidas-4 (DPP-4, DPP4) är ett enzym som klyver och därigenom inaktiverar inkretinhormonerna GLP-1 och GIP. Dipeptidylpeptidas 4-hämmare är läkemedel som hämmar effekten hos DPP4.

Referenser

  1. ↑ Zheng, Zhikai; Zong, Yao; Ma, Yiyang; Tian, Yucheng; Pang, Yidan; Zhang, Changqing (18 september 2024). ”Glucagon-like peptide-1 receptor: mechanisms and advances in therapy”. Signal Transduction and Targeted Therapy 9 (1): sid. 234. doi:10.1038/s41392-024-01931-z. ISSN 2059-3635. PMID 39289339. Läst 30 april 2026. ”Subsequently, GLP-1 undergoes enzymatic degradation facilitated by dipeptidyl peptidase IV (DPP-4), leading to the loss of its biological efficacy.”.
  2. ↑ Wolfe, M. Michael; Boylan, Michael O.; Chin, William W. (15 juli 2025). ”Glucose-Dependent Insulinotropic Polypeptide in Incretin Physiology: Role in Health and Disease”. Endocrine Reviews 46 (4): sid. 479–500. doi:10.1210/endrev/bnaf006. ISSN 1945-7189. PMID 39951489. Läst 30 april 2026. ”After its release into the circulation, GIP rapidly undergoes proteolytic degradation catalyzed by the serine protease dipeptidyl peptidase-4, which cleaves the 2 NH2-terminal amino acids of GIP, resulting in the inactivation of its biological properties.”.