Mepiprazol

Mepiprazol, İspanya'da pazarlanan ve ek antidepresan özelliklere sahip fenilpiperazin grubunun anksiyolitik bir ilacıdır. 5-HT2A ve α1-adrenerjik reseptör antagonisti olarak görev yapar, geri alımını inhibe eder ve serotonin, dopamin ve norepinefrin salınımını değişen oranlarda indükler; bir serotonin antagonisti ve geri alım inhibitörü (SARI) olarak tanımlanmıştır. İrritabl bağırsak sendromu (IBS) olan hastalarda mepiprazolün kontrollü klinik denemeleri yapılmıştır ve ilacın bazı hastalarda IBS semptomlarını hafifletmede bazı yararları olduğu görülmüştür. Trazodon, nefazodon ve etoperidon gibi diğer fenilpiperazinlere benzer şekilde, mepiprazol aktif metabolit olarak mCPP üretir.

Kaynakça

  1. 1 2 "Mepiprazole, a new psychotropic drug: effects on uptake and retention of monoamines in rat brain synaptosomes". Psychopharmacology. 48 (3): 295-301. August 1976. doi:10.1007/BF00496865. PMID 9660.
  2. ↑ J. Elks (14 Kasım 2014). The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies. Springer. ss. 768-. ISBN 978-1-4757-2085-3.
  3. ↑ Swiss Pharmaceutical Society (2000). Index Nominum 2000: International Drug Directory (Book with CD-ROM). Boca Raton: Medpharm Scientific Publishers. ISBN 3-88763-075-0.
  4. ↑ Pöldinger W (1975). "Clinical trial of 3-methyl-5-(beta-N'-(N-m-chlorophenylpiperazino)ethyl)-pyrazole dihydrochloride (Mepiprazol) in the therapy of psychovegetative disorders". International Pharmacopsychiatry. 10 (1): 1-8. doi:10.1159/000468162. PMID 1095510.
  5. ↑ "[A controlled double-blind crossover study of the efficacy of mepiprazol (EMD 16.923) and of diazepam in the treatment of neurotic disorders]". Acta Psychiatrica Belgica (Fransızca). 75 (3): 320-33. May 1975. PMID 769484.
  6. ↑ "[Psychopharmological research with EMD 16-923 in patients with different degrees of anxiety]". Neurología, Neurocirugía, Psiquiatría (İspanyolca). 17 (1): 29-33. 1976. PMID 1052713.
  7. ↑ "Evidence that blood pressure reduction by serotonin antagonists is related to alpha receptor blockade in spontaneously hypertensive rats". Hypertension. 5 (5): 676-81. 1983. doi:10.1161/01.hyp.5.5.676. PMID 6311738.
  8. ↑ "Central action of mepiprazole". Polish Journal of Pharmacology and Pharmacy. 32 (4): 475-84. 1980. PMID 7255266.
  9. 1 2 "The effect of mepiprazole on central monoamine neurons. Evidence for increased 5-hydroxytryptamine and dopamine receptor activity". European Journal of Pharmacology. 35 (1): 93-108. January 1976. doi:10.1016/0014-2999(76)90304-6. PMID 943291.
  10. ↑ Fagiolini (2012). "Rediscovering Trazodone for the Treatment of Major Depressive Disorder". CNS Drugs. 26 (12): 1033-1049. doi:10.1007/s40263-012-0010-5. ISSN 1172-7047. PMC 3693429 Özgürce erişilebilir. PMID 23192413.
  11. ↑ "Controlled clinical trial of mepiprazole in irritable bowel syndrome". The British Medical Journal. 4 (5935): 16-8. October 1974. doi:10.1136/bmj.4.5935.16. PMC 1612118 Özgürce erişilebilir. PMID 4609545.
  12. ↑ "1-m-Chlorophenylpiperazine is an active metabolite common to the psychotropic drugs trazodone, etoperidone and mepiprazole". The Journal of Pharmacy and Pharmacology. 34 (10): 674-5. October 1982. doi:10.1111/j.2042-7158.1982.tb04701.x. PMID 6128394.