Safranal

Safranal

Kimyasal Adı	2,6,6-trimethyl-1,3- cyclohexadiene-1-carboxaldehyde
Kimyasal formül	C₁₀H₁₄O
Molekül ağırlığı	150.21 g/mol
CAS numarası	116-26-7
Yoğunluk	0.9734 g/cm³
SMILES	CC1(C)C(C=O)=C(C)C=CC1
Kaynakça ve sorumluluk reddi

Safranal, Safran (Crocus sativus) çiçeklerinden elde edilen safranda bulunan bir organik bileşiktir. Safranın aromasından başlıca sorumlu olan bileşenidir.

Zeaksantin isimli karotenoidin yıkımı sonucunda, pikrokrosin yoluyla meydana geldiği düşünülmektedir.

Farmakoloji

Safranal, etkili bir antikonvülsandır, GABA_A reseptörlerine agonist olarak etki eder. Safranal ayrıca antioksidan ve serbest radikal toplayıcı etkisine sahiptir ve in vitro kanser hücrelerine sitotoksik etkisi vardır.

Kaynakça

↑ Hosseinzadeh H, Talebzadeh F. (2005). "Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice". Fitoterapia. 76 (7–8). ss. 722-4. PMID 16253437.
↑ Hosseinzadeh H, Sadeghnia HR. (2006). "Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems". Phytomedicine. ? (?). ss. ?. PMID 16707256.
↑ Hosseinzadeh H, Sadeghnia HR. (2005). "Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus". J Pharm Pharm Sci. 8 (3). ss. 394-9. PMID 16401389.
↑ Assimopoulou AN, Sinakos Z, Papageorgiou VP. (2005). "Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents". Phytother Res. 19 (11). ss. 997-1000. PMID 16317646.
↑ Escribano J, Alonso GL, Coca-Prados M, Fernandez JA. (1996). "Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro". Cancer Lett. Cilt 100. ss. 23-30. PMID 8620447.

Organik kimya ile ilgili bu madde taslak seviyesindedir. Madde içeriğini genişleterek Vikipedi'ye katkı sağlayabilirsiniz.

[anticonvulsant-Hosseinzadeh-1] Hosseinzadeh H, Talebzadeh F. (2005). "Anticonvulsant evaluation of safranal and crocin from Crocus sativus in mice". Fitoterapia. 76 (7–8). ss. 722-4. PMID 16253437.

[protective-effect-Hosseinzadeh-2] Hosseinzadeh H, Sadeghnia HR. (2006). "Protective effect of safranal on pentylenetetrazol-induced seizures in the rat: Involvement of GABAergic and opioids systems". Phytomedicine. ? (?). ss. ?. PMID 16707256.

[Safranal-a-constituent-Hosseinzadeh-3] Hosseinzadeh H, Sadeghnia HR. (2005). "Safranal, a constituent of Crocus sativus (saffron), attenuated cerebral ischemia induced oxidative damage in rat hippocampus". J Pharm Pharm Sci. 8 (3). ss. 394-9. PMID 16401389.

[Radical-scavenging-Assimopoulou-4] Assimopoulou AN, Sinakos Z, Papageorgiou VP. (2005). "Radical scavenging activity of Crocus sativus L. extract and its bioactive constituents". Phytother Res. 19 (11). ss. 997-1000. PMID 16317646.

[Crocin-safranal-Escribano-5] Escribano J, Alonso GL, Coca-Prados M, Fernandez JA. (1996). "Crocin, safranal and picrocrocin from saffron (Crocus sativus L.) inhibit the growth of human cancer cells in vitro". Cancer Lett. Cilt 100. ss. 23-30. PMID 8620447.