2-Cl-HHC

2-Cl-HHC
Identifiers
  • (6aR,10aR)-6,6,9-trimethyl-2-chloro-3-pentyl-6a,7,8,9,10,10a-hexahydrobenzo[c]chromen-1-ol
Chemical and physical data
FormulaC21H31ClO2
Molar mass350.93 g·mol−1
3D model (JSmol)
  • CC1(C)Oc2cc(CCCCC)c(Cl)c(O)c2[C@@H]2CC(C)CC[C@H]21
  • InChI=InChI=1S/C21H31ClO2/c1-5-6-7-8-14-12-17-18(20(23)19(14)22)15-11-13(2)9-10-16(15)21(3,4)24-17/h12-13,15-16,23H,5-11H2,1-4H3/t13?,15-,16-/m1/s1
  • Key:PHJMMAFCYCJUOX-GNHXQJIDSA-N

2-Cl-HHC (2-chloro-hexahydrocannabinol) is a chlorinated derivative of hexahydrocannabinol which has been sold as a designer drug, and is presumed to have cannabinoid activity. It was first identified as a component of a cannabinoid e-cigarette liquid in Japan in 2025 which was represented as being free from illicit cannabinoids such as THC. The active ingredient instead was identified as a mixture of 2-Cl-HHC and 4-Cl-HHC along with 2,4-dichloro-HHC and trace amounts of other chlorinated phytocannabinoid derivatives, as well as the ester Δ9-THCB-O-butanoate. While chlorinated derivatives of THC such as 9-Cl-HHC had previously been identified, their biological activity has not been studied. 2-Cl-HHC has since been added to the controlled drugs list in Hungary.

4-Cl-HHC
9-Cl-HHC

See also

References

  1. ↑ Tanaka R, Kawamura M, Ito M, Kikura-Hanajiri R (November 2025). "Identification of Novel THC Analogs: Chloro Derivatives of Hexahydrocannabinol and Tetrahydrocannabibutol Butanoate in an Oil Product Obtained in Japan". Drug Testing and Analysis. 17 (11): 2170–2177. doi:10.1002/dta.3927. PMID 40880172.
  2. ↑ Banijamali AR, Van Der Schyf CJ, Makriyannis A (February 1998). "Addition and elimination of HCl to tetrahydrocannabinol isomers. A method for the preparation of stereospecifically 2H‐labeled cannabinoids". Journal of Labelled Compounds and Radiopharmaceuticals. 41 (2): 121–130.
  3. ↑ Sárosi P (2026-07-08). "18 ÚJ SZER Kerül Tiltólistára: de ELÉG-E a Tiltás?". Drogriporter.
  4. ↑ "Társadalmi egyeztetés az új pszichoaktív anyagok szabályozásáról". kormany.hu.