AB-MDMSBA

AB-MDMSBA
Legal status
Legal status
  • AU: Unscheduled (No known pharmacological activity)
  • DE: NpSG (Industrial and scientific use only)
Identifiers
  • N-[(2S)-1-amino-3-methyl-1-oxobutan-2-yl]-3-(dimethylsulfamoyl)-4-methylbenzamide
PubChem CID
ChemSpider
Chemical and physical data
FormulaC15H23N3O4S
Molar mass341.43 g·mol−1
3D model (JSmol)
  • CC1=C(C=C(C=C1)C(=O)N[C@@H](C(C)C)C(=O)N)S(=O)(=O)N(C)C
  • InChI=InChI=1S/C15H23N3O4S/c1-9(2)13(14(16)19)17-15(20)11-7-6-10(3)12(8-11)23(21,22)18(4)5/h6-9,13H,1-5H3,(H2,16,19)(H,17,20)/t13-/m0/s1
  • Key:KYNAATZHNRULED-ZDUSSCGKSA-N

AB-MDMSBA is a novel synthetic compound that has been sold as a designer drug. It has been detected by drug checking services in Australia and New Zealand being misrepresented as a benzodiazepine.

It is structurally similar to other arylsulfonamide-based synthetic cannabinoids such as QMPSB. This class of synthetic cannabinoid has previously been targeted toward greater selectivity of the cannabinoid receptor CB2 over CB1. However, AD-MDMSBA itself binds with very low affinity and is unlikely to cause receptor activation. It may serve as a pre-cursor to synthesize other cannabinoids.

See also

References

  1. ↑ "Synthetic cannabinoid AB-MDMSBA found in 'benzodiazepine' samples - The Know". The Know - Australian drug alerts, all in one place. 2024-12-10. Retrieved 2025-06-10.
  2. ↑ "New synthetic cannabinoid misrepresented as a benzodiazepine". High Alert. Retrieved 2025-06-10.
  3. ↑ Lebon F, Christophe B, Burton M, De Ryck M, Quéré L, Lambeng N (January 2007). "Arylsulfonamides as a new class of cannabinoid CB1 receptor ligands: Identification of a lead and initial SAR studies". Bioorganic & Medicinal Chemistry Letters. 17 (1): 272–277. doi:10.1016/j.bmcl.2006.09.049. PMID 17027269.
  4. ↑ Ajello CW, Worm K, Bourdonnec BL, Savolainen MA, O'Hare H, Cassel JA, et al. (January 2009). "CB2 selective sulfamoyl benzamides: Optimization of the amide functionality". Bioorganic & Medicinal Chemistry Letters. 19 (2): 309–313. doi:10.1016/j.bmcl.2008.11.091. PMID 19091565.
  5. ↑ Patel M, Ganeshan D, Horgan I, Partington H, Glass M (June 2026). "AB-MDMSBA-Not a Synthetic Cannabinoid Receptor Agonist". Pharmacology Research & Perspectives. 14 (3) e70278. John Wiley & Sons, Ltd. doi:10.1002/prp2.70278. PMC 13246468. PMID 42260731.