ACOT7

ACOT7
Identifiers
Aliases	ACOT7, ACH1, ACT, BACH, CTE-II, LACH, LACH1, hBACH, acyl-CoA thioesterase 7
External IDs	OMIM: 602587; MGI: 1917275; GeneCards: ACOT7
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2QQ2
Enzyme activity
Gene location (Human)
Chr.	Chromosome 1 (human)
End	6,393,767 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	152,356,312 bp
RNA expression pattern
	Top expressed in
	lateral nuclear group of thalamus; ; prefrontal cortex; ; right frontal lobe; ; Brodmann area 9; ; pars compacta; ; pons; ; endothelial cell; ; anterior cingulate cortex; ; middle temporal gyrus; ; spinal ganglia;
	Top expressed in
	seminiferous tubule; ; anterior horn of spinal cord; ; medial dorsal nucleus; ; facial motor nucleus; ; dentate gyrus of hippocampal formation granule cell; ; central gray substance of midbrain; ; medulla oblongata; ; nucleus of stria terminalis; ; medial vestibular nucleus; ; perirhinal cortex;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	palmitoyl-CoA hydrolase activity; fatty-acyl-CoA binding; protein homodimerization activity; carboxylic ester hydrolase activity; long-chain fatty acyl-CoA binding; protein binding; hydrolase activity; acyl-CoA hydrolase activity; myristoyl-CoA hydrolase activity; thiolester hydrolase activity;
Cellular component	cytosol; nucleoplasm; mitochondrion; extracellular exosome; cytoplasm;
Biological process	medium-chain fatty acid biosynthetic process; medium-chain fatty-acyl-CoA catabolic process; long-chain fatty-acyl-CoA catabolic process; coenzyme A biosynthetic process; palmitic acid biosynthetic process; acyl-CoA metabolic process; lipid metabolism; fatty acid metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	11332
	70025
	ENSG00000097021
	ENSMUSG00000028937
	O00154
	Q91V12
NM_181866; NM_007274; NM_181862; NM_181863; NM_181864;
	NM_181865
NM_001146057; NM_001146058; NM_133348; NM_001369273; NM_001369274;
	NM_001369275; NM_001369276
	NP_009205; NP_863654; NP_863655; NP_863656
NP_001139529; NP_001139530; NP_579926; NP_001356202; NP_001356203;
	NP_001356204; NP_001356205
	Wikidata
View/Edit Human	View/Edit Mouse

Cytosolic acyl coenzyme A thioester hydrolase is an enzyme that in humans is encoded by the ACOT7 gene.

This gene encodes a member of the acyl coenzyme family. The encoded protein hydrolyzes the CoA thioester of palmitoyl-CoA and other long-chain fatty acids. Decreased expression of this gene may be associated with mesial temporal lobe epilepsy. Alternatively spliced transcript variants encoding distinct isoforms with different subcellular locations have been characterized.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000097021 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028937 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.
↑ Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.
↑ Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.
1 2 "Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

External links

Human ACOT7 genome location and ACOT7 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000097021 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028937 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10578051-5] Yamada J, Kurata A, Hirata M, Taniguchi T, Takama H, Furihata T, Shiratori K, Iida N, Takagi-Sakuma M, Watanabe T, Kurosaki K, Endo T, Suga T (Mar 2000). "Purification, molecular cloning, and genomic organization of human brain long-chain acyl-CoA hydrolase". J Biochem. 126 (6): 1013–9. doi:10.1093/oxfordjournals.jbchem.a022544. PMID 10578051.

[pmid16103133-6] Hunt MC, Yamada J, Maltais LJ, Wright MW, Podesta EJ, Alexson SE (Aug 2005). "A revised nomenclature for mammalian acyl-CoA thioesterases/hydrolases". J Lipid Res. 46 (9): 2029–32. doi:10.1194/jlr.E500003-JLR200. PMID 16103133.

[pmid16940157-7] Hunt MC, Rautanen A, Westin MA, Svensson LT, Alexson SE (Aug 2006). "Analysis of the mouse and human acyl-CoA thioesterase (ACOT) gene clusters shows that convergent, functional evolution results in a reduced number of human peroxisomal ACOTs". FASEB J. 20 (11): 1855–64. doi:10.1096/fj.06-6042com. PMID 16940157. S2CID 501610.

[entrez-8] 1 2 "Entrez Gene: ACOT7 acyl-CoA thioesterase 7".

ACOT7

References

Further reading

External links