ACTL8

ACTL8
Identifiers
Aliases	ACTL8, CT57, actin like 8
External IDs	GeneCards: ACTL8
Gene location (Human)
Chr.	Chromosome 1 (human)
End	17,827,063 bp
RNA expression pattern
	Top expressed in
	oocyte; ; secondary oocyte; ; testicle; ; gonad; ; right testis; ; left testis; ; mucosa of transverse colon; ; rectum; ; frontal lobe; ; Cortex of frontal lobe;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding; cytoskeletal protein-membrane anchor activity;
Cellular component	cytoplasm; cytoskeleton; centrosome; dynactin complex; cell cortex region;
Biological process	epithelial cell differentiation; establishment of mitotic spindle orientation; nuclear migration along microtubule;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	81569
	n/a
	ENSG00000117148
	n/a
	Q9H568
	n/a
	NM_030812
	n/a
	NP_110439
	n/a
	Wikidata
View/Edit Human

Actin-like 8 is a protein in humans that is encoded by the ACTL8 gene. It is a protein that is used in making the intracellular architecture of cells. ACTL8 expression is significantly upregulated in gastric cancer cells and is strongly associated with negative patient outcomes.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117148 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Actin-like 8". Retrieved 2012-11-02.
↑ Yu W, Zhang Q, Ali M, Chen B, Sun Q, Wang D (October 2024). "ACTL8 Promotes the Progression of Gastric Cancer Through PI3K/AKT/mTOR Signaling Pathway". Digestive Diseases and Sciences. 69 (10): 3786–3798. doi:10.1007/s10620-024-08649-6. PMC 11489201. PMID 39322809.

External links

Human ACTL8 genome location and ACTL8 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117148 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-3] "Entrez Gene: Actin-like 8". Retrieved 2012-11-02.

[4] Yu W, Zhang Q, Ali M, Chen B, Sun Q, Wang D (October 2024). "ACTL8 Promotes the Progression of Gastric Cancer Through PI3K/AKT/mTOR Signaling Pathway". Digestive Diseases and Sciences. 69 (10): 3786–3798. doi:10.1007/s10620-024-08649-6. PMC 11489201. PMID 39322809.