Adenosine deaminase 2

ADA2
Identifiers
Aliases	ADA2, ADGF, IDGFL, PAN, SNEDS, CECR1, cat eye syndrome chromosome region, candidate 1, adenosine deaminase 2, VAIHS
External IDs	OMIM: 607575; GeneCards: ADA2
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	3LGD, 3LGG
Enzyme activity
Gene location (Human)
Chr.	Chromosome 22 (human)
End	17,258,235 bp
RNA expression pattern
	Top expressed in
	monocyte; ; granulocyte; ; bone marrow cell; ; right uterine tube; ; spleen; ; blood; ; lymph node; ; thymus; ; sperm; ; gallbladder;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	deaminase activity; zinc ion binding; adenosine receptor binding; adenosine deaminase activity; heparin binding; hydrolase activity; protein homodimerization activity; metal ion binding; proteoglycan binding; growth factor activity;
Cellular component	extracellular region; extracellular space; azurophil granule lumen; cytosol;
Biological process	multicellular organism development; neutrophil degranulation; hypoxanthine salvage; inosine biosynthetic process; adenosine catabolic process; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	51816
	n/a
	ENSG00000093072
	n/a
	Q9NZK5
	n/a
NM_001282225; NM_001282226; NM_001282227; NM_001282228; NM_001282229;
	NM_017424; NM_177405
	n/a
NP_001269154; NP_001269155; NP_001269156; NP_001269157; NP_001269158;
	NP_803124
	n/a
	Wikidata
View/Edit Human

Adenosine deaminase 2 is an enzyme that in humans is encoded by the ADA2 gene (previously CECR1).

This enzyme is one of the two main types of adenosine deaminase found in humans, which regulate levels of adenosine, a signaling molecule. This specific enzyme is secreted by monocytes which are differentiating, and may be involved in the regulation of cell proliferation and differentiation.

It may be responsible for some of the phenotypic features associated with cat eye syndrome.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000093072 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Riazi MA, Brinkman-Mills P, Nguyen T, Pan H, Phan S, Ying F, et al. (May 2000). "The human homolog of insect-derived growth factor, CECR1, is a candidate gene for features of cat eye syndrome". Genomics. 64 (3): 277–285. doi:10.1006/geno.1999.6099. PMID 10756095.
1 2 Hoppe W, Gassmann J, Hunsmann N, Schramm HJ, Sturm M (August 1975). "Comments on the paper "Relevance of three-dimensional reconstructions of stain distributions for structural analysis of biomolecules"". Hoppe-Seyler's Zeitschrift Fur Physiologische Chemie. 356 (8): 1317–1320. doi:10.1515/bchm2.1975.356.2.1317. PMID 51816. Archived from the original on 2010-12-05.

External links

Human CECR1 genome location and CECR1 gene details page in the UCSC Genome Browser.

Charlab R, Valenzuela JG, Andersen J, Ribeiro JM (2001). "The invertebrate growth factor/CECR1 subfamily of adenosine deaminase proteins". Gene. 267 (1): 13–22. doi:10.1016/S0378-1119(01)00393-6. PMID 11311551.
Footz TK, Brinkman-Mills P, Banting GS, Maier SA, Riazi MA, Bridgland L, et al. (June 2001). "Analysis of the cat eye syndrome critical region in humans and the region of conserved synteny in mice: a search for candidate genes at or near the human chromosome 22 pericentromere". Genome Research. 11 (6): 1053–1070. doi:10.1101/gr.154901. PMC 311098. PMID 11381032.
Collins JE, Wright CL, Edwards CA, Davis MP, Grinham JA, Cole CG, et al. (2004). "A genome annotation-driven approach to cloning the human ORFeome". Genome Biology. 5 (10) R84. doi:10.1186/gb-2004-5-10-r84. PMC 545604. PMID 15461802.
Zavialov AV, Engström A (2006). "Human ADA2 belongs to a new family of growth factors with adenosine deaminase activity". The Biochemical Journal. 391 (Pt 1): 51–57. doi:10.1042/BJ20050683. PMC 1237138. PMID 15926889.
Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, et al. (2005). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Research. 12 (2): 117–126. doi:10.1093/dnares/12.2.117. PMID 16303743.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000093072 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Riazi_2000-3] Riazi MA, Brinkman-Mills P, Nguyen T, Pan H, Phan S, Ying F, et al. (May 2000). "The human homolog of insect-derived growth factor, CECR1, is a candidate gene for features of cat eye syndrome". Genomics. 64 (3): 277–285. doi:10.1006/geno.1999.6099. PMID 10756095.

[entrez-4] 1 2 Hoppe W, Gassmann J, Hunsmann N, Schramm HJ, Sturm M (August 1975). "Comments on the paper "Relevance of three-dimensional reconstructions of stain distributions for structural analysis of biomolecules"". Hoppe-Seyler's Zeitschrift Fur Physiologische Chemie. 356 (8): 1317–1320. doi:10.1515/bchm2.1975.356.2.1317. PMID 51816. Archived from the original on 2010-12-05.

Adenosine deaminase 2

References

External links

Further reading