ADAMTSL1

ADAMTSL1
Identifiers
Aliases	ADAMTSL1, ADAMTSL-1, ADAMTSR1, C9orf94, PUNCTIN, ADAMTS like 1
External IDs	OMIM: 609198; MGI: 1924989; GeneCards: ADAMTSL1
Gene location (Human)
Chr.	Chromosome 9 (human)
End	18,910,950 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	86,346,622 bp
RNA expression pattern
	Top expressed in
	sural nerve; ; Descending thoracic aorta; ; ascending aorta; ; body of uterus; ; smooth muscle tissue; ; testicle; ; left uterine tube; ; left adrenal cortex; ; myometrium; ; right adrenal cortex;
	Top expressed in
	zygote; ; lumbar subsegment of spinal cord; ; otolith organ; ; sciatic nerve; ; secondary oocyte; ; utricle; ; primary oocyte; ; efferent ductule; ; calvaria; ; umbilical cord;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	peptidase activity; hydrolase activity;
Cellular component	extracellular region; endoplasmic reticulum lumen;
Biological process	proteolysis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	92949
	77739
	ENSG00000178031
	ENSMUSG00000066113
	Q8N6G6
	Q8BLI0
	NM_001040272; NM_052866; NM_139238; NM_139264
	NM_029967; NM_172542; NM_001368621
	NP_001035362; NP_443098
	NP_084243; NP_001355550
	Wikidata
View/Edit Human	View/Edit Mouse

ADAMTS-like protein 1 is a protein that in humans is encoded by the ADAMTSL1 gene.

This gene encodes a secreted protein resembling members of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motif) family. This protein lacks the propeptide region and the metalloproteinase and disintegrin-like domains, which are typical of the ADAMTS family, but contains other ADAMTS domains, including the thrombospondin type 1 motif. This protein may have important functions in the extracellular matrix. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000178031 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066113 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.
↑ Hirohata S, Wang LW, Miyagi M, Yan L, Seldin MF, Keene DR, Crabb JW, Apte SS (Apr 2002). "Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix". J Biol Chem. 277 (14): 12182–9. doi:10.1074/jbc.M109665200. PMID 11805097.
1 2 "Entrez Gene: ADAMTSL1 ADAMTS-like 1".

External links

Human ADAMTSL1 genome location and ADAMTSL1 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 9 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000178031 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000066113 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9628581-5] Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (Aug 1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro". DNA Res. 5 (1): 31–9. doi:10.1093/dnares/5.1.31. PMID 9628581.

[pmid11805097-6] Hirohata S, Wang LW, Miyagi M, Yan L, Seldin MF, Keene DR, Crabb JW, Apte SS (Apr 2002). "Punctin, a novel ADAMTS-like molecule, ADAMTSL-1, in extracellular matrix". J Biol Chem. 277 (14): 12182–9. doi:10.1074/jbc.M109665200. PMID 11805097.

[entrez-7] 1 2 "Entrez Gene: ADAMTSL1 ADAMTS-like 1".

ADAMTSL1

References

Further reading

External links