ADI1

ADI1
Identifiers
Aliases	ADI1, APL1, ARD, Fe-ARD, MTCBP1, Ni-ARD, SIPL, mtnD, HMFT1638, acireductone dioxygenase 1
External IDs	OMIM: 613400; MGI: 2144929; GeneCards: ADI1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	4QGN
Enzyme activity
Gene location (Mouse)
Chr.	Chromosome 12 (mouse)
End	28,732,174 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; kidney; ; ascending aorta; ; duodenum; ; left ventricle; ; right coronary artery; ; left coronary artery; ; gallbladder; ; fundus; ; left adrenal gland;
	Top expressed in
	left lobe of liver; ; muscle of thigh; ; Paneth cell; ; right kidney; ; triceps brachii muscle; ; embryo; ; crypt of lieberkuhn of small intestine; ; medial head of gastrocnemius muscle; ; tail of embryo; ; vastus lateralis muscle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	protein binding; dioxygenase activity; metal ion binding; oxidoreductase activity; acireductone dioxygenase [iron(II)-requiring activity]; iron ion binding;
Cellular component	cytosol; membrane; plasma membrane; nucleus; cytoplasm;
Biological process	methionine biosynthetic process; cellular amino acid biosynthetic process; L-methionine salvage from methylthioadenosine; methionine metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry
	55256
	104923
	n/a
	ENSMUSG00000020629
	Q9BV57
	Q99JT9
	NM_001306077; NM_018269
	NM_134052
	NP_001293006; NP_060739
	NP_598813
	Wikidata
View/Edit Human	View/Edit Mouse

The human ADI1 gene encodes the enzyme 1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase.

Function

The enzyme belongs to the aci-reductone dioxygenase family of metal-binding enzymes, which are involved in methionine salvage. This enzyme may regulate mRNA processing in the nucleus, and may carry out different functions depending on its localization.

Clinical significance

Diseases associated with ADI1 include Klebsiella, and refsum disease.

ADI1 is capable for supporting hepatitis C virus replication in an otherwise non-permissive cell line. Mouse hepatoma cells coexpressing human CD81 and ADI1/Sip-L supported HCV infection and replication. Human ADI1//Sip-L over-expression in 293 cells enhances cell entry but not replication of HCV.