AGAP3

AGAP3
Identifiers
Aliases	AGAP3, AGAP-3, CENTG3, CRAG, MRIP-1, cnt-g3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3
External IDs	OMIM: 616813; MGI: 2183446; GeneCards: AGAP3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3IHW
Gene location (Human)
Chr.	Chromosome 7 (human)
End	151,144,436 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	24,707,045 bp
RNA expression pattern
	Top expressed in
	right hemisphere of cerebellum; ; right frontal lobe; ; Brodmann area 9; ; cingulate gyrus; ; anterior cingulate cortex; ; prefrontal cortex; ; amygdala; ; hypothalamus; ; nucleus accumbens; ; anterior pituitary;
	Top expressed in
	superior frontal gyrus; ; dentate gyrus of hippocampal formation granule cell; ; primary visual cortex; ; neural layer of retina; ; ventricular zone; ; lip; ; muscle of thigh; ; cerebellar cortex; ; otic vesicle; ; saccule;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding; GTP binding; metal ion binding; GTPase activator activity; GTPase activity; polyubiquitin modification-dependent protein binding;
Cellular component	membrane; nucleus; cytoplasm; cell periphery;
Biological process	positive regulation of GTPase activity; signal transduction; cellular response to reactive oxygen species; proteasome-mediated ubiquitin-dependent protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	116988
	213990
	ENSG00000133612
	ENSMUSG00000023353
	Q96P47; Q86ST5
	Q8VHH5
NM_001042535; NM_001281300; NM_001308304; NM_001308305; NM_031946;
	NM_001350102; NM_001350103; NM_001350104
	NM_001256431; NM_139153; NM_001359881
NP_001036000; NP_001268229; NP_001295233; NP_001295234; NP_114152;
	NP_001337031; NP_001337032; NP_001337033; NP_001036000.1; NP_001295233.1; NP_001295234.1
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 is an enzyme that in humans is encoded by the AGAP3 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000133612 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023353 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: CENTG3 centaurin, gamma 3".

External links

Human AGAP3 genome location and AGAP3 gene details page in the UCSC Genome Browser.

Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization". Nat. Biotechnol. 24 (10): 1285–1292. doi:10.1038/nbt1240. PMID 16964243. S2CID 14294292.
Qin Q, Inatome R, Hotta A, et al. (2006). "A novel GTPase, CRAG, mediates promyelocytic leukemia protein-associated nuclear body formation and degradation of expanded polyglutamine protein". J. Cell Biol. 172 (4): 497–504. doi:10.1083/jcb.200505079. PMC 2063670. PMID 16461359.
Meurer S, Pioch S, Wagner K, et al. (2005). "AGAP1, a novel binding partner of nitric oxide-sensitive guanylyl cyclase". J. Biol. Chem. 279 (47): 49346–49354. doi:10.1074/jbc.M410565200. PMID 15381706.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
Surks HK, Richards CT, Mendelsohn ME (2004). "Myosin phosphatase-Rho interacting protein. A new member of the myosin phosphatase complex that directly binds RhoA". J. Biol. Chem. 278 (51): 51484–51493. doi:10.1074/jbc.M305622200. PMID 14506264.
Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–772. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
Xia C, Ma W, Stafford LJ, et al. (2003). "GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins". Mol. Cell. Biol. 23 (7): 2476–2488. doi:10.1128/MCB.23.7.2476-2488.2003. PMC 150724. PMID 12640130.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000133612 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023353 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: CENTG3 centaurin, gamma 3".

AGAP3

References

External links

Further reading