AKTIP

AKTIP
Identifiers
Aliases	AKTIP, FT1, FTS, AKT interacting protein
External IDs	OMIM: 608483; MGI: 3693832; GeneCards: AKTIP
Gene location (Human)
Chr.	Chromosome 16 (human)
End	53,504,411 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	91,926,604 bp
RNA expression pattern
	Top expressed in
	secondary oocyte; ; pons; ; muscle of thigh; ; C1 segment; ; amniotic fluid; ; prefrontal cortex; ; amygdala; ; substantia nigra; ; anterior cingulate cortex; ; vastus lateralis muscle;
	Top expressed in
	right kidney; ; medial vestibular nucleus; ; deep cerebellar nuclei; ; neural layer of retina; ; globus pallidus; ; central gray substance of midbrain; ; superior frontal gyrus; ; lateral hypothalamus; ; dorsomedial hypothalamic nucleus; ; cerebellar cortex;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	ubiquitin-like protein transferase activity; protein binding; ubiquitin protein ligase binding; ubiquitin protein ligase activity;
Cellular component	HOPS complex; plasma membrane; membrane; FHF complex; cytosol; cytoplasm;
Biological process	protein transport; positive regulation of protein binding; positive regulation of protein phosphorylation; lysosome organization; early endosome to late endosome transport; endosome organization; endosome to lysosome transport; apoptotic process; protein ubiquitination;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	64400
	14339
	ENSG00000166971
	ENSMUSG00000031667
	Q9H8T0
	Q64362
	NM_001012398; NM_001308325; NM_022476
NM_010241; NM_001302266; NM_001302267; NM_001302268; NM_001302337;
	NM_001358934; NM_001358935; NM_001358936; NM_001358937; NM_001358938
	NP_001012398; NP_001295254; NP_071921
NP_001289195; NP_001289196; NP_001289197; NP_001289266; NP_034371;
	NP_001345863; NP_001345864; NP_001345865; NP_001345866; NP_001345867
	Wikidata
View/Edit Human	View/Edit Mouse

AKT-interacting protein is a protein that in humans is encoded by the AKTIP gene.

The mouse homolog of this gene produces fused toes and thymic hyperplasia in heterozygous mutant animals while homozygous mutants die in early development. This gene may play a role in apoptosis as these morphological abnormalities are caused by altered patterns of programmed cell death. The protein encoded by this gene is similar to the ubiquitin ligase domain of other ubiquitin-conjugating enzymes but lacks the conserved cysteine residue that enables those enzymes to conjugate ubiquitin to the target protein. This protein interacts directly with serine/threonine kinase protein kinase B (PKB)/Akt and modulates PKB activity by enhancing the phosphorylation of PKB's regulatory sites. Alternative splicing results in two transcript variants encoding the same protein.

Interactions

AKTIP has been shown to interact with AKT1.

Molecular genetics

The association between the AKTIP gene variants in a sample of 273 bipolar patients using 3 single-nucleotide polymorphisms has been investigated. No association between suicidal behavior and AKTIP variants nor any interaction between AKTIP and AKT1 polymorphisms was observed.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166971 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031667 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Fluhmann B, Muff R, Hunziker W, Fischer JA, Born W (Feb 1995). "A human orphan calcitonin receptor-like structure". Biochem Biophys Res Commun. 206 (1): 341–7. doi:10.1006/bbrc.1995.1047. PMID 7818539.
↑ Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (Jun 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J Biol Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.
1 2 "Entrez Gene: AKTIP AKT interacting protein".
↑ Remy, Ingrid; Michnick Stephen W (Feb 2004). "Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt". Mol. Cell. Biol. 24 (4): 1493–504. doi:10.1128/MCB.24.4.1493-1504.2004. ISSN 0270-7306. PMC 344167. PMID 14749367.
↑ Magno LA, Miranda DM, Neves FS, Pimenta GJ, Mello MP, De Marco LA, Correa H, Romano-Silva MA (January 2010). "Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients". Genes Brain Behav. 9 (4): 411–8. doi:10.1111/j.1601-183X.2010.00571.x. PMID 20132317. S2CID 36267195.

External links

Human AKTIP genome location and AKTIP gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Lesche R, Peetz A, van der Hoeven F, Rüther U (1998). "Ft1, a novel gene related to ubiquitin-conjugating enzymes, is deleted in the Fused toes mouse mutation". Mamm. Genome. 8 (12): 879–83. doi:10.1007/s003359900604. PMID 9383278. S2CID 10988499.
Lesche R, Rüther U (1998). "Close linkage of p130 and Ft1 is conserved among mammals". Mamm. Genome. 9 (3): 253–5. doi:10.1007/s003359900737. PMID 9501314. S2CID 34220560.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Remy I, Michnick SW (2004). "Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt". Mol. Cell. Biol. 24 (4): 1493–504. doi:10.1128/MCB.24.4.1493-1504.2004. PMC 344167. PMID 14749367.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome". Cell. 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. hdl:11858/00-001M-0000-0010-8592-0. PMID 16169070. S2CID 8235923.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 16 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166971 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031667 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7818539-5] Fluhmann B, Muff R, Hunziker W, Fischer JA, Born W (Feb 1995). "A human orphan calcitonin receptor-like structure". Biochem Biophys Res Commun. 206 (1): 341–7. doi:10.1006/bbrc.1995.1047. PMID 7818539.

[pmid8626685-6] Aiyar N, Rand K, Elshourbagy NA, Zeng Z, Adamou JE, Bergsma DJ, Li Y (Jun 1996). "A cDNA encoding the calcitonin gene-related peptide type 1 receptor". J Biol Chem. 271 (19): 11325–9. doi:10.1074/jbc.271.19.11325. PMID 8626685.

[entrez-7] 1 2 "Entrez Gene: AKTIP AKT interacting protein".

[pmid14749367-8] Remy, Ingrid; Michnick Stephen W (Feb 2004). "Regulation of apoptosis by the Ft1 protein, a new modulator of protein kinase B/Akt". Mol. Cell. Biol. 24 (4): 1493–504. doi:10.1128/MCB.24.4.1493-1504.2004. ISSN 0270-7306. PMC 344167. PMID 14749367.

[pmid20132317-9] Magno LA, Miranda DM, Neves FS, Pimenta GJ, Mello MP, De Marco LA, Correa H, Romano-Silva MA (January 2010). "Association between AKT1 but not AKTIP genetic variants and increased risk for suicidal behavior in bipolar patients". Genes Brain Behav. 9 (4): 411–8. doi:10.1111/j.1601-183X.2010.00571.x. PMID 20132317. S2CID 36267195.

AKTIP

Interactions

Molecular genetics

References

External links

Further reading