ANAPC5 Protein-coding gene in humans
Anaphase-promoting complex subunit 5 is an enzyme that in humans is encoded by the ANAPC5 gene .
The anaphase-promoting complex (APC) consists of at least eight protein subunits, including ANAPC5
(this gene) , CDC27 (APC3; MIM 116946), CDC16 (APC6; MIM 603461), and CDC23 (APC8; MIM 603462).[supplied by OMIM]
References
1 2 3 GRCh38: Ensembl release 89: ENSG00000089053 – Ensembl , May 20171 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029472 – Ensembl , May 2017↑ "Human PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ "Mouse PubMed Reference:" . National Center for Biotechnology Information, U.S. National Library of Medicine .↑ Yu H, Peters JM, King RW, Page AM, Hieter P, Kirschner MW (March 1998). "Identification of a cullin homology region in a subunit of the anaphase-promoting complex". Science . 279 (5354). New York, N.Y.: 1219– 1222. Bibcode :1998Sci...279.1219Y . doi :10.1126/science.279.5354.1219 . PMID 9469815 . 1 2 "Entrez Gene: ANAPC5 anaphase promoting complex subunit 5" .1 2 3 Vodermaier HC, Gieffers C, Maurer-Stroh S, Eisenhaber F, Peters JM (September 2003). "TPR subunits of the anaphase-promoting complex mediate binding to the activator protein CDH1" . Current Biology . 13 (17): 1459– 1468. Bibcode :2003CBio...13.1459V . doi :10.1016/S0960-9822(03)00581-5 PMID 12956947 . S2CID 5942532 . ↑ Sumara I, Vorlaufer E, Gieffers C, Peters BH, Peters JM (November 2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase" . The Journal of Cell Biology . 151 (4): 749– 762. doi :10.1083/jcb.151.4.749 . PMC 2169443 PMID 11076961 . 1 2 Koloteva-Levine N, Pinchasi D, Pereman I, Zur A, Brandeis M, Elroy-Stein O (May 2004). "The Apc5 subunit of the anaphase-promoting complex/cyclosome interacts with poly(A) binding protein and represses internal ribosome entry site-mediated translation" . Molecular and Cellular Biology . 24 (9): 3577– 3587. doi :10.1128/MCB.24.9.3577-3587.2004 . PMC 387753 PMID 15082755 . ↑ Gmachl M, Gieffers C, Podtelejnikov AV, Mann M, Peters JM (August 2000). "The RING-H2 finger protein APC11 and the E2 enzyme UBC4 are sufficient to ubiquitinate substrates of the anaphase-promoting complex" . Proceedings of the National Academy of Sciences of the United States of America . 97 (16): 8973– 8978. Bibcode :2000PNAS...97.8973G . doi :10.1073/pnas.97.16.8973 PMC 16806 PMID 10922056 .
Further reading
Grossberger R, Gieffers C, Zachariae W, Podtelejnikov AV, Schleiffer A, Nasmyth K, et al. (May 1999). "Characterization of the DOC1/APC10 subunit of the yeast and the human anaphase-promoting complex" . The Journal of Biological Chemistry . 274 (20): 14500– 14507. doi :10.1074/jbc.274.20.14500 PMID 10318877 . Gieffers C, Peters BH, Kramer ER, Dotti CG, Peters JM (September 1999). "Expression of the CDH1-associated form of the anaphase-promoting complex in postmitotic neurons" . Proceedings of the National Academy of Sciences of the United States of America . 96 (20): 11317– 11322. Bibcode :1999PNAS...9611317G . doi :10.1073/pnas.96.20.11317 PMC 18031 PMID 10500174 . Kraft C, Herzog F, Gieffers C, Mechtler K, Hagting A, Pines J, et al. (December 2003). "Mitotic regulation of the human anaphase-promoting complex by phosphorylation" . The EMBO Journal . 22 (24): 6598– 6609. doi :10.1093/emboj/cdg627 . PMC 291822 PMID 14657031 . Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, et al. (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins" . Proceedings of the National Academy of Sciences of the United States of America . 101 (33): 12130– 12135. Bibcode :2004PNAS..10112130B . doi :10.1073/pnas.0404720101 PMC 514446 PMID 15302935 . Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (March 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science . 307 (5715). New York, N.Y.: 1621– 1625. Bibcode :2005Sci...307.1621B . doi :10.1126/science.1105776 . PMID 15761153 . S2CID 39457788 . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, et al. (October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature . 437 (7062): 1173– 1178. Bibcode :2005Natur.437.1173R . doi :10.1038/nature04209 . PMID 16189514 . S2CID 4427026 . Turnell AS, Stewart GS, Grand RJ, Rookes SM, Martin A, Yamano H, et al. (December 2005). "The APC/C and CBP/p300 cooperate to regulate transcription and cell-cycle progression". Nature . 438 (7068): 690– 695. Bibcode :2005Natur.438..690T . doi :10.1038/nature04151 . PMID 16319895 . S2CID 4432156 .
