APC2

APC2
Identifiers
Aliases	APC2, APCL, adenomatosis polyposis coli 2, WNT signaling pathway regulator, APC regulator of WNT signaling pathway 2, MRT74
External IDs	OMIM: 612034; MGI: 1346052; GeneCards: APC2
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1DEB, 1EMU, 1JPP, 1M5I, 1T08, 1TH1, 1V18, 2RQU, 3AU3, 3NMW, 3NMX, 3NMZ, 3QHE, 3RL7, 3RL8, 3T7U, 4G69
Gene location (Human)
Chr.	Chromosome 19 (human)
End	1,473,244 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	80,154,097 bp
RNA expression pattern
	Top expressed in
	paraflocculus of cerebellum; ; cerebellar vermis; ; middle frontal gyrus; ; Brodmann area 10; ; inferior olivary nucleus; ; ganglionic eminence; ; frontal pole; ; ventral tegmental area; ; dorsal motor nucleus of vagus nerve; ; inferior ganglion of vagus nerve;
	Top expressed in
	ganglionic eminence; ; dentate gyrus of hippocampal formation granule cell; ; superior frontal gyrus; ; neural tube; ; lumbar subsegment of spinal cord; ; primary visual cortex; ; Rostral migratory stream; ; cerebellar cortex; ; perirhinal cortex; ; entorhinal cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	beta-catenin binding; microtubule binding; protein binding; gamma-catenin binding;
Cellular component	cytoplasm; Golgi apparatus; microtubule cytoskeleton; actin filament; perinuclear region of cytoplasm; cytoplasmic microtubule; catenin complex; microtubule; cytoskeleton; lamellipodium membrane; filamentous actin; cytosol; midbody; intercellular bridge; beta-catenin destruction complex; postsynapse;
Biological process	negative regulation of Wnt signaling pathway; Wnt signaling pathway; negative regulation of canonical Wnt signaling pathway; microtubule cytoskeleton organization; activation of GTPase activity; cell fate specification; negative regulation of microtubule depolymerization; pattern specification process; cell migration; regulation of cell differentiation; positive regulation of protein catabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10297
	23805
	ENSG00000115266
	ENSMUSG00000020135
	O95996
	Q9Z1K7
	NM_005883; NM_001351273
NM_011789; NM_001372237; NM_001372238; NM_001372239; NM_001372240;
	NM_001372241
	NP_005874; NP_001338202
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Adenomatous polyposis coli protein 2 is a protein that in humans is encoded by the APC2 gene. This is a dual-functional protein which is especially prevalant in the developing brain, and involved in cell signaling (specifically Wnt signaling) and stabilizing the cytoskeleton.

Function

Wnt signaling

Frizzled receptors are a type of cell receptor involved in a variety of functions including embryonic development and cell proliferation. These receptors trigger a cascade of reactions called the Wnt signaling pathway that eventually leads to interaction with the DNA via the protein beta-catenin, which affects which proteins get produced by the cell. The APC2 protein promotes the formation of a protein complex which is involved in breaking down the protein beta-catenin.

Cytoskeleton

The APC2 protein stabilizes microtubules, which are part of the cell cytoskeleton. It may also be involved in the regulation of actin fibers my means of GTPase activation (specifically the Rho family).

Medical Significance

Pathogenic mutations the APC2 gene have been associated with brain disorders, and in particular it is the cause of two disorders called complex cortical dysplasia, with other brain malformations 10 and intellectual developmental disorder, autosomal recessive 74.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000115266 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020135 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "APC2 APC regulator of Wnt signaling pathway 2". Entrez Gene. NCBI. Retrieved 2026-09-19.
1 2 Xue C, Chu Q, Shi Q, Zeng Y, Lu J, Li L (2025-04-04). "Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances". Signal transduction and targeted therapy. 10 (1). doi:10.1038/s41392-025-02142-w.
1 2 "Adenomatous polyposis coli protein 2". uniprot.org. UniProt consortium. Retrieved 2026-09-19.
↑ "APC2 REGULATOR OF WNT SIGNALING PATHWAY 2; APC2". Online Mendelian Inheritance in Man. Johns Hopkins University. Retrieved 2026-09-19.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000115266 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000020135 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 "APC2 APC regulator of Wnt signaling pathway 2". Entrez Gene. NCBI. Retrieved 2026-09-19.

[Xue2025-6] 1 2 Xue C, Chu Q, Shi Q, Zeng Y, Lu J, Li L (2025-04-04). "Wnt signaling pathways in biology and disease: mechanisms and therapeutic advances". Signal transduction and targeted therapy. 10 (1). doi:10.1038/s41392-025-02142-w.

[uniprot-7] 1 2 "Adenomatous polyposis coli protein 2". uniprot.org. UniProt consortium. Retrieved 2026-09-19.

[8] "APC2 REGULATOR OF WNT SIGNALING PATHWAY 2; APC2". Online Mendelian Inheritance in Man. Johns Hopkins University. Retrieved 2026-09-19.