ARF4

ARF4
Identifiers
Aliases	ARF4, ARF2, ADP ribosylation factor 4
External IDs	OMIM: 601177; MGI: 99433; GeneCards: ARF4
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1Z6X
Gene location (Human)
Chr.	Chromosome 3 (human)
End	57,598,220 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	26,386,239 bp
RNA expression pattern
	Top expressed in
	tibia; ; parietal pleura; ; visceral pleura; ; germinal epithelium; ; corpus epididymis; ; mucosa of sigmoid colon; ; pancreatic epithelial cell; ; parotid gland; ; epithelium of nasopharynx; ; stromal cell of endometrium;
	Top expressed in
	genital tubercle; ; tail of embryo; ; ventricular zone; ; right kidney; ; esophagus; ; embryo; ; embryo; ; lip; ; yolk sac; ; dentate gyrus of hippocampal formation granule cell;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; epidermal growth factor receptor binding; GTP binding; protein binding; GTPase activity;
Cellular component	cytosol; Golgi apparatus; membrane; dendritic spine; intracellular anatomical structure; ruffle membrane; extracellular exosome; extracellular matrix; cytoplasm; plasma membrane; glutamatergic synapse;
Biological process	protein ADP-ribosylation; small GTPase mediated signal transduction; negative regulation of apoptotic process; regulation of reactive oxygen species metabolic process; endoplasmic reticulum to Golgi vesicle-mediated transport; activation of phospholipase D activity; protein transport; cell migration; vesicle-mediated transport; positive regulation of transcription by RNA polymerase II; retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum; transport; dendritic spine development; intracellular protein transport; Golgi to plasma membrane transport; epidermal growth factor receptor signaling pathway; brain development; learning; apical protein localization; establishment or maintenance of epithelial cell apical/basal polarity; response to axon injury; regulation of synapse organization; protein localization to cilium; regulation of postsynapse organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	378
	11843
	ENSG00000168374
	ENSMUSG00000021877
	P18085
	P61750
	NM_001660
	NM_007479
	NP_001651
	NP_031505
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribosylation factor 4 is a protein that in humans is encoded by the ARF4 gene.

Gene

ADP-ribosylation factor 4 (ARF4) is a member of the human ARF gene family.

The gene products include 5 ARF proteins and 11 ARF-like proteins and constitute 1 family of the RAS superfamily. The ARF proteins are categorized as class I (ARF1 and ARF3), class II (ARF4, this gene and ARF5) and class III (ARF6). The members of each class share a common gene organization. The ARF4 gene spans approximately 12kb and contains six exons and five introns. The ARF4 is the most divergent member of the human ARFs. Conflicting Map positions at 3p14 or 3p21 have been reported for this gene.

Function

These genes encode small Guanine-nucleotide binding proteins (G proteins) that play a role in vesicular trafficking and as activators of phospholipase D.