ARFGEF1

ARFGEF1
Identifiers
Aliases	ARFGEF1, ARFGEP1, BIG1, P200, ADP ribosylation factor guanine nucleotide exchange factor 1
External IDs	OMIM: 604141; MGI: 2442988; GeneCards: ARFGEF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3LTL, 5EE5
Gene location (Human) Chr. Chromosome 8 (human) Band 8q13.2 Start 67,173,511 bp End 67,343,781 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 A2 Start 10,207,796 bp End 10,302,895 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad secondary oocyte epithelium of nasopharynx sural nerve bronchial epithelial cell testicle mucosa of sigmoid colon jejunal mucosa bone marrow tibia Top expressed in gastrula crypt of lieberkuhn of small intestine submandibular gland transitional epithelium of urinary bladder cumulus cell zygote knee joint triceps brachii muscle cardiac muscle tissue of left ventricle plantaris muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity guanyl-nucleotide exchange factor activity myosin binding protein binding protein kinase A regulatory subunit binding Cellular component cytosol Golgi apparatus membrane nuclear matrix Golgi membrane nucleoplasm trans-Golgi network nucleolus small nuclear ribonucleoprotein complex perinuclear region of cytoplasm nucleus cytoplasm Biological process endomembrane system organization positive regulation of protein kinase B signaling negative regulation of actin filament polymerization Golgi organization positive regulation of wound healing regulation of ARF protein signal transduction negative regulation of GTPase activity protein transport neuron projection development regulation of establishment of cell polarity exocytosis positive regulation of GTPase activity vesicle-mediated transport Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 10565 211673 Ensembl ENSG00000066777 ENSMUSG00000067851 UniProt Q9Y6D6 G3X9K3 RefSeq (mRNA) NM_006421 NM_001102430 RefSeq (protein) NP_006412 NP_001095900 Location (UCSC) Chr 8: 67.17 – 67.34 Mb Chr 1: 10.21 – 10.3 Mb PubMed search
Wikidata
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Brefeldin A-inhibited guanine nucleotide-exchange protein 1 is a protein that in humans is encoded by the ARFGEF1 gene.

Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.

Interactions

ARFGEF1 has been shown to interact with FKBP2, ARFGEF2 and PRKAR1A.