ARFRP1

ARFRP1
Identifiers
Aliases	ARFRP1, ARL18, ARP, Arp1, ADP ribosylation factor related protein 1
External IDs	OMIM: 604699; MGI: 1923938; GeneCards: ARFRP1
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.33 Start 63,698,642 bp End 63,708,025 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H4 Start 180,999,483 bp End 181,007,197 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in beta cell apex of heart olfactory bulb mucosa of transverse colon spleen right frontal lobe right hemisphere of cerebellum stromal cell of endometrium granulocyte right auricle of heart Top expressed in saccule neural layer of retina otic placode otic vesicle medullary collecting duct ventricular zone external carotid artery muscle of thigh internal carotid artery granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding GTP binding protein binding GTPase activity Cellular component trans-Golgi network Golgi apparatus intracellular anatomical structure membrane cytosol trans-Golgi network membrane Biological process Golgi to plasma membrane protein transport retrograde transport, endosome to Golgi gastrulation signal transduction protein localization to Golgi apparatus intracellular protein transport protein localization to organelle small GTPase mediated signal transduction Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 10139 76688 Ensembl ENSG00000101246 ENSMUSG00000038671 UniProt Q13795 Q8BXL7 RefSeq (mRNA) NM_001134758 NM_001267544 NM_001267545 NM_001267546 NM_001267547 NM_001267548 NM_001267549 NM_003224 NM_001165991 NM_001165992 NM_001165995 NM_029702 RefSeq (protein) NP_001128230 NP_001254473 NP_001254474 NP_001254475 NP_001254476 NP_001254477 NP_001254478 NP_003215 NP_001254476.1 NP_001159463 NP_001159464 NP_001159467 NP_083978 Location (UCSC) Chr 20: 63.7 – 63.71 Mb Chr 2: 181 – 181.01 Mb PubMed search
Wikidata
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ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

Function

The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors.

Interactions

ARFRP1 has been shown to interact with PSCD1.