ARFRP1

ARFRP1
Identifiers
Aliases	ARFRP1, ARL18, ARP, Arp1, ADP ribosylation factor related protein 1
External IDs	OMIM: 604699; MGI: 1923938; GeneCards: ARFRP1
Gene location (Human)
Chr.	Chromosome 20 (human)
End	63,708,025 bp
Gene location (Mouse)
Chr.	Chromosome 2 (mouse)
End	181,007,197 bp
RNA expression pattern
	Top expressed in
	beta cell; ; apex of heart; ; olfactory bulb; ; mucosa of transverse colon; ; spleen; ; right frontal lobe; ; right hemisphere of cerebellum; ; stromal cell of endometrium; ; granulocyte; ; right auricle of heart;
	Top expressed in
	saccule; ; neural layer of retina; ; otic placode; ; otic vesicle; ; medullary collecting duct; ; ventricular zone; ; external carotid artery; ; muscle of thigh; ; internal carotid artery; ; granulocyte;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; GTP binding; protein binding; GTPase activity;
Cellular component	trans-Golgi network; Golgi apparatus; intracellular anatomical structure; membrane; cytosol; trans-Golgi network membrane;
Biological process	Golgi to plasma membrane protein transport; retrograde transport, endosome to Golgi; gastrulation; signal transduction; protein localization to Golgi apparatus; intracellular protein transport; protein localization to organelle; small GTPase mediated signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10139
	76688
	ENSG00000101246
	ENSMUSG00000038671
	Q13795
	Q8BXL7
NM_001134758; NM_001267544; NM_001267545; NM_001267546; NM_001267547;
	NM_001267548; NM_001267549; NM_003224
	NM_001165991; NM_001165992; NM_001165995; NM_029702
NP_001128230; NP_001254473; NP_001254474; NP_001254475; NP_001254476;
	NP_001254477; NP_001254478; NP_003215; NP_001254476.1
	NP_001159463; NP_001159464; NP_001159467; NP_083978
	Wikidata
View/Edit Human	View/Edit Mouse

ADP-ribosylation factor-related protein 1 is a protein that in humans is encoded by the ARFRP1 gene.

Function

The protein encoded by this gene is a membrane-associated GTP-ase and localizes to the plasma membrane. It is related to the ADP-ribosylation factor (ARF) and ARF-like (ARL) genes. The gene is located in a gene cluster that includes the a gene (M68) that is overexpressed in some tumors.

Interactions

ARFRP1 has been shown to interact with PSCD1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101246 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038671 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schurmann A, Massmann S, Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol Chem. 270 (51): 30657–63. doi:10.1074/jbc.270.51.30657. PMID 8530503.
1 2 "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1".
↑ Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D". J. Biol. Chem. 274 (14): 9744–51. doi:10.1074/jbc.274.14.9744. PMID 10092663.

External links

ARFRP1 human gene location in the UCSC Genome Browser.
ARFRP1 human gene details in the UCSC Genome Browser.

This article on a gene on human chromosome 20 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101246 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000038671 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8530503-5] Schurmann A, Massmann S, Joost HG (Jan 1996). "ARP is a plasma membrane-associated Ras-related GTPase with remote similarity to the family of ADP-ribosylation factors". J Biol Chem. 270 (51): 30657–63. doi:10.1074/jbc.270.51.30657. PMID 8530503.

[entrez-6] 1 2 "Entrez Gene: ARFRP1 ADP-ribosylation factor related protein 1".

[pmid10092663-7] Schürmann A, Schmidt M, Asmus M, Bayer S, Fliegert F, Koling S, Massmann S, Schilf C, Subauste MC, Voss M, Jakobs KH, Joost HG (April 1999). "The ADP-ribosylation factor (ARF)-related GTPase ARF-related protein binds to the ARF-specific guanine nucleotide exchange factor cytohesin and inhibits the ARF-dependent activation of phospholipase D". J. Biol. Chem. 274 (14): 9744–51. doi:10.1074/jbc.274.14.9744. PMID 10092663.

ARFRP1

Function

Interactions

References

Further reading

External links