ARPP-21

ARPP21
Identifiers
Aliases	ARPP21, ARPP-21, R3HDM3, RCS, TARPP, cAMP regulated phosphoprotein 21kDa, cAMP regulated phosphoprotein 21
External IDs	OMIM: 605488; MGI: 107562; GeneCards: ARPP21
Gene location (Human)
Chr.	Chromosome 3 (human)
End	35,794,496 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	112,235,938 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; putamen; ; nucleus accumbens; ; caudate nucleus; ; middle temporal gyrus; ; cerebellar hemisphere; ; right hemisphere of cerebellum; ; primary visual cortex; ; Brodmann area 23; ; right frontal lobe;
	Top expressed in
	olfactory tubercle; ; globus pallidus; ; piriform cortex; ; nucleus accumbens; ; superior frontal gyrus; ; temporal lobe; ; cingulate gyrus; ; visual cortex; ; primary motor cortex; ; amygdala;
	More reference expression data
	n/a
Gene ontology
Molecular function	calmodulin binding; nucleic acid binding; molecular function;
Cellular component	cytoplasm; cellular component;
Biological process	cellular response to heat; biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	10777
	74100
	ENSG00000172995
	ENSMUSG00000032503
	Q9UBL0
	Q9DCB4
NM_001025068; NM_001025069; NM_001267616; NM_001267617; NM_001267618;
	NM_001267619; NM_016300; NM_198399
NM_001177615; NM_001177616; NM_001177617; NM_001177618; NM_001177619;
	NM_001177620; NM_001177623; NM_028755; NM_033264
NP_001020239; NP_001020240; NP_001254545; NP_001254546; NP_001254547;
	NP_001254548; NP_057384; NP_938409
NP_001171086; NP_001171087; NP_001171088; NP_001171089; NP_001171090;
	NP_001171091; NP_001171094; NP_083031; NP_150289; NP_001348929; NP_001348930; NP_001348931; NP_001348932; NP_001348933; NP_001348934; NP_001348935; NP_001348936; NP_001348937; NP_001348938; NP_001348939; NP_001348940; NP_001348941; NP_001348942; NP_001348943; NP_001348944; NP_001348945; NP_001348946; NP_001348947; NP_001348948; NP_001348949; NP_001348950; NP_001348951; NP_001348952; NP_001348953; NP_001348954; NP_001348955; NP_001348956; NP_001348957; NP_001348958; NP_001348959; NP_001348960; NP_001348961; NP_001348962; NP_001348963; NP_001348964; NP_001348965; NP_001348966; NP_001348967; NP_001348968; NP_001348969; NP_001348970
	Wikidata
View/Edit Human	View/Edit Mouse

Cyclic AMP-regulated phosphoprotein, 21 kDa, also known as ARPP21, is a human gene. Research published in March 2026 identified ARPP21 as one of the genes contributing to overall risk of developing amyotrophic lateral sclerosis (ALS). A new high-impact ARPP21 variant was identified (p.P747L). Furthermore, the p.P563L mutation, previously established as the cause of ALS in seven unrelated families from Spain, was confirmed to be associated with a more aggressive disease course.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000172995 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032503 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "ARPP21 cAMP regulated phosphoprotein 21".
↑ https://www.nature.com/articles/s41588-026-02535-9
↑ https://jnnp.bmj.com/content/96/2/132

External links

Human ARPP21 genome location and ARPP21 gene details page in the UCSC Genome Browser.

Brill LM, Salomon AR, Ficarro SB, Mukherji M, Stettler-Gill M, Peters EC (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry". Anal. Chem. 76 (10): 2763–2772. doi:10.1021/ac035352d. PMID 15144186.
Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–9548. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
Bonaldo MF, Lennon G, Soares MB (1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
Brené S, Lindefors N, Ehrlich M, Taubes T, Horiuchi A, Kopp J, Hall H, Sedvall G, Greengard P, Persson H (1994). "Expression of mRNAs encoding ARPP-16/19, ARPP-21, and DARPP-32 in human brain tissue". J. Neurosci. 14 (3 Pt 1): 985–98. doi:10.1523/JNEUROSCI.14-03-00985.1994. PMC 6577526. PMID 8120638.
Rakhilin SV, Olson PA, Nishi A, Starkova NN, Fienberg AA, Nairn AC, Surmeier DJ, Greengard P (2004). "A network of control mediated by regulator of calcium/calmodulin-dependent signaling". Science. 306 (5696): 698–701. Bibcode:2004Sci...306..698R. doi:10.1126/science.1099961. PMID 15499021. S2CID 12127149.
Caporaso GL, Bibb JA, Snyder GL, Valle C, Rakhilin S, Fienberg AA, Hemmings HC, Nairn AC, Greengard P (2000). "Drugs of abuse modulate the phosphorylation of ARPP-21, a cyclic AMP-regulated phosphoprotein enriched in the basal ganglia". Neuropharmacology. 39 (9): 1637–44. doi:10.1016/s0028-3908(99)00230-0. PMID 10854908. S2CID 11927459.
Nair AG, Bhalla US, Hellgren Kotaleski J (2016). "Role of DARPP-32 and ARPP-21 in the Emergence of Temporal Constraints on Striatal Calcium and Dopamine Integration". PLOS Comput Biol. 12 (9) e1005080. Bibcode:2016PLSCB..12E5080N. doi:10.1371/journal.pcbi.1005080. PMC 5008828. PMID 27584878.

This article on a gene on human chromosome 3 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000172995 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032503 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "ARPP21 cAMP regulated phosphoprotein 21".

[6] ttps://www.nature.com/articles/s41588-026-02535-9

[7] ttps://jnnp.bmj.com/content/96/2/132

ARPP-21

References

External links

Further reading