ATPase ASNA1

GET3
Identifiers
Aliases	GET3, ARSA-I, ARSA1, ASNA-I, TRC40, hASNA-I, arsA arsenite transporter, ATP-binding, homolog 1 (bacterial), ASNA1, Guided Entry Of Tail-Anchored Proteins Factor 3, ATPase
External IDs	OMIM: 601913; MGI: 1928379; GeneCards: GET3
Gene location (Human)
Chr.	Chromosome 19 (human)
End	12,748,323 bp
Gene location (Mouse)
Chr.	Chromosome 8 (mouse)
End	85,751,910 bp
RNA expression pattern
	Top expressed in
	monocyte; ; stromal cell of endometrium; ; prefrontal cortex; ; right adrenal gland; ; apex of heart; ; right adrenal cortex; ; right frontal lobe; ; left adrenal gland; ; right testis; ; islet of Langerhans;
	Top expressed in
	choroid plexus of fourth ventricle; ; yolk sac; ; epiblast; ; dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; superior frontal gyrus; ; primary visual cortex; ; central gray substance of midbrain; ; perirhinal cortex; ; medulla oblongata;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	nucleotide binding; ATPase activity; protein binding; hydrolase activity; ATP binding; arsenite transmembrane transporter activity; metal ion binding; transporter activity; ATPase-coupled transmembrane transporter activity;
Cellular component	cytoplasm; nucleolus; extracellular exosome; endoplasmic reticulum membrane; nucleus; endoplasmic reticulum; GET complex;
Biological process	IRE1-mediated unfolded protein response; inorganic anion transport; transport; posttranslational protein targeting to endoplasmic reticulum membrane; arsenite transport; protein insertion into ER membrane; tail-anchored membrane protein insertion into ER membrane;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	439
	56495
	ENSG00000198356
	ENSMUSG00000052456
	O43681
	O54984
	NM_004317
	NM_019652; NM_001357202; NM_001357203
	NP_004308; NP_001358417; NP_001358418
	NP_062626; NP_001344131; NP_001344132
	Wikidata
View/Edit Human	View/Edit Mouse

ATPase GET3 (also known as ATPase ASNA1, arsenical pump-driving ATPase and arsenite-stimulated ATPase) is an enzyme that in humans is encoded by the gene GET3 (previously ASNA1).

Function

GET3 is the human homolog of the bacterial arsA gene. In E. coli, arsA ATPase is the catalytic component of a multisubunit oxyanion pump that is responsible for resistance to arsenicals and antimonials.

Interactions

The protein GET3 is found to interact with FAM71D according to STRING

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000198356 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052456 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kurdi-Haidar B, Aebi S, Heath D, Enns RE, Naredi P, Hom DK, Howell SB (Feb 1997). "Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter". Genomics. 36 (3): 486–91. doi:10.1006/geno.1996.0494. PMID 8884272.
1 2 "Entrez Gene: ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)".
↑ "STRING 10". Archived from the original on 2013-05-15. Retrieved 2015-05-11.

External links

Human ASNA1 genome location and ASNA1 gene details page in the UCSC Genome Browser.

Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Kurdi-Haidar B, Heath D, Aebi S, Howell SB (1998). "Biochemical characterization of the human arsenite-stimulated ATPase (hASNA-I)". J. Biol. Chem. 273 (35): 22173–6. doi:10.1074/jbc.273.35.22173. PMID 9712828.
Kurdi-Haidar B, Hom DK, Flittner DE, et al. (1998). "Dual cytoplasmic and nuclear distribution of the novel arsenite-stimulated human ATPase (hASNA-I)". J. Cell. Biochem. 71 (1): 1–10. doi:10.1002/(SICI)1097-4644(19981001)71:1<1::AID-JCB1>3.0.CO;2-#. PMID 9736449. S2CID 196597195.
Kurdi-Haidar B, Heath D, Lennon G, Howell SB (2000). "Chromosomal localization and genomic structure of the human arsenite-stimulated ATPase (hASNA-I)". Somat. Cell Mol. Genet. 24 (5): 307–11. doi:10.1023/B:SCAM.0000007134.16744.8b. PMID 10696239. S2CID 11936516.
Kao G, Nordenson C, Still M, et al. (2007). "ASNA-1 positively regulates insulin secretion in C. elegans and mammalian cells". Cell. 128 (3): 577–87. doi:10.1016/j.cell.2006.12.031. PMID 17289575. S2CID 2120123.
Stefanovic S, Hegde RS (2007). "Identification of a targeting factor for posttranslational membrane protein insertion into the ER". Cell. 128 (6): 1147–59. doi:10.1016/j.cell.2007.01.036. PMID 17382883. S2CID 16802797.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000198356 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052456 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8884272-5] Kurdi-Haidar B, Aebi S, Heath D, Enns RE, Naredi P, Hom DK, Howell SB (Feb 1997). "Isolation of the ATP-binding human homolog of the arsA component of the bacterial arsenite transporter". Genomics. 36 (3): 486–91. doi:10.1006/geno.1996.0494. PMID 8884272.

[entrez-6] 1 2 "Entrez Gene: ASNA1 arsA arsenite transporter, ATP-binding, homolog 1 (bacterial)".

[7] "STRING 10". Archived from the original on 2013-05-15. Retrieved 2015-05-11.

ATPase ASNA1

Function

Interactions

References

External links

Further reading