ATAD3B

ATAD3B
Alliases	TOB3, AAA-TOB3, KIAA 1273
External IDs	NCBI: AAH02542.1
Gene Location (Human)

ATAD3B
Identifiers
Aliases	ATAD3B, AAA-TOB3, TOB3, ATPase family, AAA domain containing 3B, ATPase family AAA domain containing 3B
External IDs	OMIM: 612317; GeneCards: ATAD3B
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,497,848 bp
RNA expression pattern
	Top expressed in
	anterior pituitary; ; sural nerve; ; mucosa of transverse colon; ; granulocyte; ; right lobe of thyroid gland; ; mucosa of ileum; ; right hemisphere of cerebellum; ; skin of leg; ; left ovary; ; left lobe of thyroid gland;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	ATP binding; nucleotide binding; zinc ion binding;
Cellular component	membrane; mitochondrial inner membrane; mitochondrion; plasma membrane; secretory granule membrane; ficolin-1-rich granule membrane;
Biological process	neutrophil degranulation; mitochondrion organization;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	83858
	n/a
	ENSG00000160072
	n/a
	Q5T9A4
	n/a
	NM_031921; NM_001317238
	n/a
	NP_001304167; NP_114127
	n/a
	Wikidata
View/Edit Human

ATPase family AAA domain-containing protein 3B (or ATAD3B) is a protein that in humans is encoded by the ATAD3B gene. ATAD3 is part of the AAA protein family. The function of ATAD3B is not yet well understood by the scientific community.

Function

ATAD3B is associated with the mitochondria. The C terminus is anchored in the mitochondrial inter membrane space.

The protein is linked with the pluripotency of stem cells. The ATAD3A gene is targeted by c-Myc which is one of four factors needed to create induced pluripotent stem (i-PS) cells from mouse embryonic fibroblasts (MEFs).

Its expression is linked to cell cycle function and tumor growth. When ATAD3B was overexpressed, cell duplication took an extra three hours by spending a longer time in G1 phase.

Dominant negative activity

A mutation in the stop codon means that ATAD3B protein 62 amino acids longer at the C-terminus compared to ATAD3A. This C-terminal extension of ATAD3B turns it into a negative regulator of ATAD3A.

Clinical significance

Abnormal expression levels of ATAD3B has been linked to chemoresistance. Overexpression of ATAD3B was the found to be the strongest factor in breast cancer survival rates.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160072 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Q5T9A4 · ATD3B_HUMAN". uniprot.org. UniProt consortium.
1 2 3 Merle N, Féraud O, Gilquin B, Hubstenberger A, Kieffer-Jacquinot S, Assard N, et al. (July 2012). "ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A". Mitochondrion. 12 (4): 441–448. doi:10.1016/j.mito.2012.05.005. PMID 22664726.
↑ Takahashi K, Yamanaka S (August 2006). "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors". Cell. 126 (4): 663–676. doi:10.1016/j.cell.2006.07.024. hdl:2433/159777. PMID 16904174. S2CID 1565219.
1 2 Hubstenberger A, Labourdette G, Baudier J, Rousseau D (September 2008). "ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties". Experimental Cell Research. 314 (15): 2870–2883. doi:10.1016/j.yexcr.2008.06.017. PMID 18639545.
↑ Li S, Rousseau D (February 2012). "ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression". Journal of Bioenergetics and Biomembranes. 44 (1): 189–197. doi:10.1007/s10863-012-9424-5. PMID 22318359. S2CID 11106754.
↑ Ovaska K, Matarese F, Grote K, Charapitsa I, Cervera A, Liu C, et al. (2013). Tucker-Kellogg G (ed.). "Integrative analysis of deep sequencing data identifies estrogen receptor early response genes and links ATAD3B to poor survival in breast cancer". PLOS Computational Biology. 9 (6) e1003100. Bibcode:2013PLSCB...9E3100O. doi:10.1371/journal.pcbi.1003100. PMC 3688481. PMID 23818839.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160072 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[uniprot-3] 1 2 "Q5T9A4 · ATD3B_HUMAN". uniprot.org. UniProt consortium.

[Merle_2012-4] 1 2 3 Merle N, Féraud O, Gilquin B, Hubstenberger A, Kieffer-Jacquinot S, Assard N, et al. (July 2012). "ATAD3B is a human embryonic stem cell specific mitochondrial protein, re-expressed in cancer cells, that functions as dominant negative for the ubiquitous ATAD3A". Mitochondrion. 12 (4): 441–448. doi:10.1016/j.mito.2012.05.005. PMID 22664726.

[5] Takahashi K, Yamanaka S (August 2006). "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors". Cell. 126 (4): 663–676. doi:10.1016/j.cell.2006.07.024. hdl:2433/159777. PMID 16904174. S2CID 1565219.

[Hubstenberger_2008-6] 1 2 Hubstenberger A, Labourdette G, Baudier J, Rousseau D (September 2008). "ATAD 3A and ATAD 3B are distal 1p-located genes differentially expressed in human glioma cell lines and present in vitro anti-oncogenic and chemoresistant properties". Experimental Cell Research. 314 (15): 2870–2883. doi:10.1016/j.yexcr.2008.06.017. PMID 18639545.

[7] Li S, Rousseau D (February 2012). "ATAD3, a vital membrane bound mitochondrial ATPase involved in tumor progression". Journal of Bioenergetics and Biomembranes. 44 (1): 189–197. doi:10.1007/s10863-012-9424-5. PMID 22318359. S2CID 11106754.

[8] Ovaska K, Matarese F, Grote K, Charapitsa I, Cervera A, Liu C, et al. (2013). Tucker-Kellogg G (ed.). "Integrative analysis of deep sequencing data identifies estrogen receptor early response genes and links ATAD3B to poor survival in breast cancer". PLOS Computational Biology. 9 (6) e1003100. Bibcode:2013PLSCB...9E3100O. doi:10.1371/journal.pcbi.1003100. PMC 3688481. PMID 23818839.