ATOH8

ATOH8
Identifiers
Aliases	ATOH8, HATH6, bHLHa21, atonal bHLH transcription factor 8
External IDs	MGI: 1918343; GeneCards: ATOH8
Gene location (Human)
Chr.	Chromosome 2 (human)
End	85,791,383 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	72,212,561 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right lung; ; tibial nerve; ; popliteal artery; ; tibial arteries; ; thoracic aorta; ; right auricle of heart; ; ascending aorta; ; apex of heart;
	Top expressed in
	spermatid; ; gastrula; ; seminiferous tubule; ; spermatocyte; ; tail of embryo; ; genital tubercle; ; endothelial cell of lymphatic vessel; ; aortic valve; ; muscle of thigh; ; ascending aorta;
	More reference expression data
	n/a
Gene ontology
Molecular function	DNA binding; protein dimerization activity; DNA-binding transcription factor activity; transcription factor binding; E-box binding; DNA-binding transcription factor activity, RNA polymerase II-specific;
Cellular component	cytoplasm; nuclear speck; nucleus; nucleoplasm;
Biological process	cell differentiation; positive regulation of endothelial cell differentiation; regulation of transcription, DNA-templated; SMAD protein signal transduction; transcription, DNA-templated; nervous system development; negative regulation of endothelial cell proliferation; positive regulation of endothelial cell migration; positive regulation of transcription, DNA-templated; multicellular organism development; tube formation; myoblast proliferation; formation of primary germ layer; negative regulation of transcription, DNA-templated; regulation of transcription by RNA polymerase II; positive regulation of gene expression; negative regulation of gene expression; positive regulation of pri-miRNA transcription by RNA polymerase II;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	84913
	71093
	ENSG00000168874
	ENSMUSG00000037621
	Q96SQ7
	Q99NA2
	NM_032827
	NM_153778
	NP_116216
	NP_722473
	Wikidata
View/Edit Human	View/Edit Mouse

Atonal bHLH transcription factor 8 is a protein that in humans is encoded by the ATOH8 gene. It is hypothesized to play a role endochondral ossification as a regulator of chondrocyte proliferation and differentiation. In addition, it also participates in the chondrogenesis of limb bud mesenchymal progenitor cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000168874 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037621 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Atonal bHLH transcription factor 8". Retrieved 2016-10-19.
↑ Schroeder N, Wuelling M, Hoffmann D, Brand-Saberi B, Vortkamp A (2019). van Wijnen A (ed.). "Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones". PLOS ONE. 14 (8) e0218230. Bibcode:2019PLoSO..1418230S. doi:10.1371/journal.pone.0218230. PMC 6709907. PMID 31449527.
↑ Takács R, Vágó J, Póliska S, Pushparaj PN, Ducza L, Kovács P, et al. (May 2023). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. PMC 10164575. PMID 36987858.

Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, et al. (2009). "Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip". American Journal of Human Genetics. 85 (5): 628–642. doi:10.1016/j.ajhg.2009.10.014. PMC 2775832. PMID 19913121.
Bailey SD, Xie C, Do R, Montpetit A, Diaz R, Mohan V, et al. (2010). "Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study". Diabetes Care. 33 (10): 2250–2253. doi:10.2337/dc10-0452. PMC 2945168. PMID 20628086.
Chen J, Dai F, Balakrishnan-Renuka A, Leese F, Schempp W, Schaller F, et al. (2011). "Diversification and molecular evolution of ATOH8, a gene encoding a bHLH transcription factor". PLOS ONE. 6 (8) e23005. Bibcode:2011PLoSO...623005C. doi:10.1371/journal.pone.0023005. PMC 3150394. PMID 21857980.
Güttsches AK, Balakrishnan-Renuka A, Kley RA, Tegenthoff M, Brand-Saberi B, Vorgerd M (2015). "ATOH8: a novel marker in human muscle fiber regeneration". Histochemistry and Cell Biology. 143 (5): 443–452. doi:10.1007/s00418-014-1299-6. PMID 25514850. S2CID 9753058.

This article on a gene on human chromosome 2 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000168874 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000037621 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Atonal bHLH transcription factor 8". Retrieved 2016-10-19.

[6] Schroeder N, Wuelling M, Hoffmann D, Brand-Saberi B, Vortkamp A (2019). van Wijnen A (ed.). "Atoh8 acts as a regulator of chondrocyte proliferation and differentiation in endochondral bones". PLOS ONE. 14 (8) e0218230. Bibcode:2019PLoSO..1418230S. doi:10.1371/journal.pone.0218230. PMC 6709907. PMID 31449527.

[7] Takács R, Vágó J, Póliska S, Pushparaj PN, Ducza L, Kovács P, et al. (May 2023). "The temporal transcriptomic signature of cartilage formation". Nucleic Acids Research. 51 (8): 3590–3617. doi:10.1093/nar/gkad210. PMC 10164575. PMID 36987858.

ATOH8

References

Further reading