LPCAT1

Search for
Structures	Swiss-model
Domains	InterPro

acyltransferase like 2
acyltransferase like 2
Identifiers
Symbol	AYTL2
Alt. symbols	LPCAT
NCBI gene	79888
HGNC	25718
OMIM	610472
RefSeq	NM_024830
UniProt	Q8NF37
Other data
EC number	2.3.1.23
Locus	Chr. 5 p15.33
Structures
Search for
Structures	Swiss-model
Domains	InterPro

LPCAT1
Identifiers
Aliases	LPCAT1, lysophosphatidylcholine acyltransferase 1, AYTL2, PFAAP3, lpcat, AGPAT10, AGPAT9, LPCAT-1, lysoPAFAT, acyltransferase like 2
External IDs	OMIM: 610472; MGI: 2384812; GeneCards: LPCAT1
Enzyme activity
Gene location (Human)
Chr.	Chromosome 5 (human)
End	1,523,962 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	73,664,541 bp
RNA expression pattern
	Top expressed in
	upper lobe of left lung; ; spleen; ; ventricular zone; ; granulocyte; ; right lung; ; ganglionic eminence; ; blood; ; lymph node; ; monocyte; ; appendix;
	Top expressed in
	left lung; ; left lung lobe; ; Rostral migratory stream; ; right lung; ; right lung lobe; ; retinal pigment epithelium; ; tibiofemoral joint; ; ciliary body; ; primary oocyte; ; fetal liver hematopoietic progenitor cell;
	More reference expression data
	n/a
Gene ontology
Molecular function	1-alkylglycerophosphocholine O-acyltransferase activity; metal ion binding; calcium ion binding; transferase activity; acyltransferase activity; 1-alkylglycerophosphocholine O-acetyltransferase activity; 1-alkenylglycerophosphocholine O-acyltransferase activity; 1-acylglycerophosphocholine O-acyltransferase activity; 1-acylglycerol-3-phosphate O-acyltransferase activity; 2-acylglycerol-3-phosphate O-acyltransferase activity;
Cellular component	integral component of membrane; Golgi apparatus; Golgi membrane; membrane; lipid droplet; endoplasmic reticulum membrane; endoplasmic reticulum; plasma membrane; azurophil granule membrane;
Biological process	phospholipid biosynthetic process; retina development in camera-type eye; lipid metabolism; phosphatidylglycerol acyl-chain remodeling; positive regulation of protein catabolic process; phosphatidic acid biosynthetic process; metabolism; surfactant homeostasis; negative regulation of phosphatidylcholine biosynthetic process; phosphatidylcholine acyl-chain remodeling; phospholipid metabolic process; phosphatidylcholine biosynthetic process; neutrophil degranulation;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	79888
	210992
	ENSG00000275079; ENSG00000153395
	ENSMUSG00000021608
	Q8NF37
	Q3TFD2
	NM_024830
	NM_145376; NM_001368681; NM_001368682
	NP_079106
	NP_663351; NP_001355610; NP_001355611
	Wikidata
View/Edit Human	View/Edit Mouse

Lysophosphatidylcholine acyltransferase 1, also known as acyltransferase like 2, is a protein in humans that is encoded by the LPCAT1 gene.

Lysophosphatidylcholine (LPC) acyltransferase (LPCAT; EC 2.3.1.23) catalyzes the conversion of LPC to phosphatidylcholine (PC) in the remodeling pathway of PC biosynthesis.

References

1 2 3 ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021608 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: Lysophosphatidylcholine acyltransferase 1". Archived from the original on December 16, 2018.
↑ Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi:10.1074/jbc.M600225200. PMID 16704971.

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[refGRCh38Ensembl-1] 1 2 3 ENSG00000153395 GRCh38: Ensembl release 89: ENSG00000275079, ENSG00000153395 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000021608 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: Lysophosphatidylcholine acyltransferase 1". Archived from the original on December 16, 2018.

[pmid16704971-6] Nakanishi H, Shindou H, Hishikawa D, Harayama T, Ogasawara R, Suwabe A, Taguchi R, Shimizu T (2006). "Cloning and characterization of mouse lung-type acyl-CoA:lysophosphatidylcholine acyltransferase 1 (LPCAT1). Expression in alveolar type II cells and possible involvement in surfactant production". J. Biol. Chem. 281 (29): 20140–7. doi:10.1074/jbc.M600225200. PMID 16704971.

LPCAT1

See also

References