Adipolin

C1QTNF12
Identifiers
Aliases	C1QTNF12, C1QDC2, CTRP12, FAM132A, family with sequence similarity 132 member A, C1q and TNF related 12
External IDs	OMIM: 616593; MGI: 1914639; GeneCards: C1QTNF12
Gene location (Human)
Chr.	Chromosome 1 (human)
End	1,246,722 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	156,051,086 bp
RNA expression pattern
	Top expressed in
	mucosa of transverse colon; ; mucosa of ileum; ; jejunal mucosa; ; duodenum; ; testicle; ; gonad; ; skin of abdomen; ; gastric mucosa; ; skin of limb; ; skin of leg;
	Top expressed in
	medullary collecting duct; ; renal corpuscle; ; Epithelium of choroid plexus; ; efferent ductule; ; condyle; ; fossa; ; retinal pigment epithelium; ; Paneth cell; ; brown adipose tissue; ; external carotid artery;
	More reference expression data
	n/a
Gene ontology
Molecular function	hormone activity;
Cellular component	extracellular region; extracellular space;
Biological process	positive regulation of glucose import; negative regulation of gluconeogenesis; positive regulation of insulin secretion involved in cellular response to glucose stimulus; positive regulation of insulin receptor signaling pathway; positive regulation of protein kinase B signaling; regulation of glucose metabolic process; negative regulation of inflammatory response; regulation of glucose import; regulation of signaling receptor activity; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	388581
	67389
	ENSG00000184163
	ENSMUSG00000023571
	Q5T7M4
	Q8R2Z0
	NM_001014980
	NM_026125
	NP_001014980
	NP_080401
	Wikidata
View/Edit Human	View/Edit Mouse

Adipolin is a protein that in humans is encoded by the C1QTNF12 gene. It is predicted to be a hormone which suppress glucose production by liver cells. It may also be an adipokine (meaning a hormone produced by fat cells), and may also function to increase the amount of glucose taken in by fat cells.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000184163 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023571 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: Family with sequence similarity 132, member A".
↑ "Q5T7M4 · ADIPL_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-07-28.

Wei Z, Lei X, Seldin MM, Wong GW (October 2012). "Endopeptidase cleavage generates a functionally distinct isoform of C1q/tumor necrosis factor-related protein-12 (CTRP12) with an altered oligomeric state and signaling specificity". J. Biol. Chem. 287 (43): 35804–14. doi:10.1074/jbc.M112.365965. PMC 3476250. PMID 22942287.
Enomoto T, Ohashi K, Shibata R, Higuchi A, Maruyama S, Izumiya Y, Walsh K, Murohara T, Ouchi N (October 2011). "Adipolin/C1qdc2/CTRP12 protein functions as an adipokine that improves glucose metabolism". J. Biol. Chem. 286 (40): 34552–8. doi:10.1074/jbc.M111.277319. PMC 3186379. PMID 21849507.
Conde J, Scotece M, López V, Gómez R, Lago F, Pino J, Gómez-Reino JJ, Gualillo O (January 2013). "Expression and modulation of adipolin/C1qdc2: a novel adipokine in human and murine ATDC-5 chondrocyte cell line". Ann. Rheum. Dis. 72 (1): 140–2. doi:10.1136/annrheumdis-2012-201693. hdl:20.500.11940/3471. PMID 22736092. S2CID 20772682.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000184163 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000023571 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: Family with sequence similarity 132, member A".

[6] "Q5T7M4 · ADIPL_HUMAN". uniprot.org. UniProt consortium. Retrieved 2026-07-28.

Adipolin

References

Further reading