Agathobacter rectalis

Agathobacter rectalis
Scientific classification Edit this classification
Domain: Bacteria
Kingdom: Bacillati
Phylum: Bacillota
Class: Clostridia
Order: Eubacteriales
Family: Lachnospiraceae
Genus: Agathobacter
Species:
A. rectalis
Binomial name
Agathobacter rectalis
Rosero et al. 2016
Type strain
ATCC 33656
Synonyms

Bacteroides rectalis,
Pseudobacterium rectale,
Roseburia rectale,
Eubacterium rectale

Agathobacter rectalis is a gram-positive, butyrate-producing, anaerobic, rod-shaped and non-spore-forming bacterium from the genus Agathobacter. A. rectalis has a single flagellate and it occurs in the rumen content of sheep and cows, and in the gut microbiome of humans. It is suggested that Eubacterium rectale is a synonym of A. rectalis, although this is not universally accepted.

A 2021 study looked at 5,700 gut microbiome samples from humans of various ages around the world; fifty species were found in over 70% of the participants. Of those, A. rectalis was the most abundant species. The study noted that A. rectalis has a large diversity in sequence identity which may be a factor in why the studies found this to be the most abundant bacterium.

Alzheimer's Disease

Patients with Alzheimer's disease can have a reduced abundance of short chain fatty acid producing bacteria, including A. rectalis: reduced numbers of A. rectalis in the gut may be a risk factor for Alzheimer's disease.

Metabolic dysfunction-associated steatotic liver disease

A. rectalis was found to be depleted in the gut microbiome of people with metabolic dysfunction-associated steatotic liver disease (MASLD) and can be used as an indicator of MASLD severity.

References

  1. 1 2 3 Rosero, J. A.; Killer, J.; Sechovcová, H.; Mrázek, J.; Benada, O.; Fliegerová, K.; Havlík, J.; Kopečný, J. (2016). "Reclassification of Eubacterium rectale (Hauduroy et al. 1937) Prévot 1938 in a new genus Agathobacter gen. nov. as Agathobacter rectalis comb. nov., and description of Agathobacter ruminis sp. nov., isolated from the rumen contents of sheep and cows". International Journal of Systematic and Evolutionary Microbiology. 66 (2): 768–773. doi:10.1099/ijsem.0.000788. hdl:11104/0259127. PMID 26619944.
  2. 1 2 3 4 5 6
    "[Eubacterium] rectale". www.uniprot.org.
  3. 1 2 3 4 5 Hiseni, Pranvera; Rudi, Knut; Wilson, Robert C.; Hegge, Finn Terje; Snipen, Lars (2021-07-31). "HumGut: a comprehensive human gut prokaryotic genomes collection filtered by metagenome data". Microbiome. 9 (1): 165. doi:10.1186/s40168-021-01114-w. ISSN 2049-2618. PMC 8325300. PMID 34330336.
  4. ↑ Sheridan, P. O.; Duncan, S. H.; Walker, A. W.; Scott, K. P.; Louis, P.; Flint, H. J. (2016). "Objections to the proposed reclassification of Eubacterium rectale as Agathobacter rectalis". International Journal of Systematic and Evolutionary Microbiology. 66 (5): 2106. doi:10.1099/ijsem.0.000969. PMID 26916277.
  5. ↑ Zuo, G.; Hao, B. (2016). "Whole-genome-based phylogeny supports the objections against the reclassification of Eubacterium rectale to Agathobacter rectalis". International Journal of Systematic and Evolutionary Microbiology. 66 (6): 2451. doi:10.1099/ijsem.0.001047. PMID 27032096.
  6. ↑ Lv, Xinhuang; Zhan, Lu; Ye, Tao; Xie, Huijia; Chen, Zhibo; Lin, Yan; Cai, Xianlei; Yang, Wenwen; Liao, Xiaolan; Liu, Jiaming; Sun, Jing (2024). "Gut commensal Agathobacter rectalis alleviates microglia-mediated neuroinflammation against pathogenesis of Alzheimer disease". iScience. 27 (11) 111116. Bibcode:2024iSci...27k1116L. doi:10.1016/j.isci.2024.111116. PMC 11532950. PMID 39498309.
  7. ↑ Medina-Méndez, Juan Manuel; Iruzubieta, Paula; Fernández-López, Raúl; Crespo, Javier; de la Cruz, Fernando (2025-12-18). "Bacterial metabolic signatures in MASLD predicted through gene-centric studies in stool metagenomes". BMC Microbiology. 26 (1): 70. doi:10.1186/s12866-025-04549-5. ISSN 1471-2180. PMC 12853991. PMID 41413769.