Apolipoprotein F

Available protein structures:
PDB	IPR026114 PF15148 (ECOD; PDBsum)
AlphaFold	IPR026114; PF15148;

Apolipoprotein F
Apolipoprotein F
Identifiers
Symbol	APOF
Pfam	PF15148
InterPro	IPR026114
PDB
Available protein structures:
PDB	IPR026114 PF15148 (ECOD; PDBsum)
AlphaFold	IPR026114; PF15148;

APOF
Identifiers
Aliases	APOF, Apo-F, LTIP, apolipoprotein F
External IDs	OMIM: 107760; MGI: 104539; GeneCards: APOF
Gene location (Human)
Chr.	Chromosome 12 (human)
End	56,362,857 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	128,106,022 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; granulocyte; ; islet of Langerhans; ; prostate; ; kidney; ; blood; ; head; ; human musculoskeletal system; ; muscular system; ; muscle;
	Top expressed in
	left lobe of liver; ; submandibular gland; ; gallbladder; ; seminal vesicula; ; sexually immature organism; ; fetal liver hematopoietic progenitor cell; ; human fetus; ; abdominal wall; ; stomach; ; ureter;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	cholesterol binding; signaling receptor binding; lipid transporter activity;
Cellular component	low-density lipoprotein particle; high-density lipoprotein particle; extracellular region; extracellular space;
Biological process	steroid metabolic process; lipid transport; cholesterol metabolic process; lipid metabolism;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	319
	103161
	ENSG00000175336
	ENSMUSG00000047631
	Q13790
	Q91V80
	NM_001638
	NM_133997
	NP_001629
	NP_598758
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein F is a protein that in humans is encoded for by the APOF gene. The product of this gene is one of the minor apolipoproteins found in plasma. This protein forms complexes with lipoproteins and may be involved in transport and/or esterification of cholesterol.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000175336 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047631 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Day JR, Albers JJ, Gilbert TL, Whitmore TE, McConathy WJ, Wolfbauer G (Oct 1994). "Purification and molecular cloning of human apolipoprotein F". Biochem Biophys Res Commun. 203 (2): 1146–51. doi:10.1006/bbrc.1994.2302. PMID 8093033.
1 2 "Entrez Gene: APOF apolipoprotein F".

External links

Human APOF genome location and APOF gene details page in the UCSC Genome Browser.

Morton RE, Gnizak HM, Greene DJ, et al. (2008). "Lipid transfer inhibitor protein (apolipoprotein F) concentration in normolipidemic and hyperlipidemic subjects". J. Lipid Res. 49 (1): 127–35. doi:10.1194/jlr.M700258-JLR200. PMID 17901467.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Kabbara A, Payet N, Cottel D, et al. (2004). "Exclusion of CYP46 and APOM as candidate genes for Alzheimer's disease in a French population". Neurosci. Lett. 363 (2): 139–43. doi:10.1016/j.neulet.2004.03.066. PMID 15172102. S2CID 27752858.
Anderson NL, Polanski M, Pieper R, et al. (2004). "The human plasma proteome: a nonredundant list developed by combination of four separate sources". Mol. Cell. Proteomics. 3 (4): 311–26. doi:10.1074/mcp.M300127-MCP200. PMID 14718574.
Paromov VM, Morton RE (2003). "Lipid transfer inhibitor protein defines the participation of high density lipoprotein subfractions in lipid transfer reactions mediated by cholesterol ester transfer protein (CETP)". J. Biol. Chem. 278 (42): 40859–66. doi:10.1074/jbc.M306580200. PMID 12907677.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Wang X, Driscoll DM, Morton RE (1999). "Molecular cloning and expression of lipid transfer inhibitor protein reveals its identity with apolipoprotein F". J. Biol. Chem. 274 (3): 1814–20. doi:10.1074/jbc.274.3.1814. PMID 9880564.
Koren E, McConathy WJ, Alaupovic P (1983). "Isolation and characterization of simple and complex lipoproteins containing apolipoprotein F from human plasma". Biochemistry. 21 (21): 5347–51. doi:10.1021/bi00264a035. PMID 6816269.
Olofsson SO, McConathy WJ, Alaupovic P (1978). "Isolation and partial characterization of a new acidic apolipoprotein (apolipoprotein F) from high density lipoproteins of human plasma". Biochemistry. 17 (6): 1032–6. doi:10.1021/bi00599a014. PMID 204339.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000175336 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000047631 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid8093033-5] Day JR, Albers JJ, Gilbert TL, Whitmore TE, McConathy WJ, Wolfbauer G (Oct 1994). "Purification and molecular cloning of human apolipoprotein F". Biochem Biophys Res Commun. 203 (2): 1146–51. doi:10.1006/bbrc.1994.2302. PMID 8093033.

[entrez-6] 1 2 "Entrez Gene: APOF apolipoprotein F".

Apolipoprotein F

References

External links

Further reading