Apolipoprotein O

Available protein structures:
PDB	IPR019166 PF09769 (ECOD; PDBsum)
AlphaFold	IPR019166; PF09769;

ApoO
ApoO
Identifiers
Symbol	ApoO
Pfam	PF09769
InterPro	IPR019166
PDB
Available protein structures:
PDB	IPR019166 PF09769 (ECOD; PDBsum)
AlphaFold	IPR019166; PF09769;

APOO
Identifiers
Aliases	APOO, FAM121B, MIC26, Mic23, My025, Apolipoprotein O, MICOS26
External IDs	OMIM: 300753; MGI: 1915566; GeneCards: APOO
Gene location (Human)
Chr.	X chromosome (human)
End	23,907,938 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	93,460,699 bp
RNA expression pattern
	Top expressed in
	decidua; ; right ventricle; ; myocardium of left ventricle; ; prefrontal cortex; ; pons; ; olfactory zone of nasal mucosa; ; lateral nuclear group of thalamus; ; triceps brachii muscle; ; Brodmann area 9; ; anterior cingulate cortex;
	Top expressed in
	quadriceps femoris muscle; ; right kidney; ; muscle of thigh; ; proximal tubule; ; muscle tissue; ; skeletal muscle tissue; ; heart; ; secondary oocyte; ; primary oocyte; ; zygote;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	high-density lipoprotein particle; extracellular region; mitochondrial inner membrane; endoplasmic reticulum membrane; very-low-density lipoprotein particle; Golgi membrane; Golgi apparatus; membrane; integral component of membrane; integral component of mitochondrial inner membrane; mitochondrion; endoplasmic reticulum; low-density lipoprotein particle; MICOS complex; extracellular space; cytosol;
Biological process	lipid transport; cristae formation; transport;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	79135
	68316
	ENSG00000184831
	ENSMUSG00000079508
	Q9BUR5
	Q9DCZ4
	NM_024122
	NM_001199337; NM_001199338; NM_001199339; NM_026673
	NP_077027
	NP_001186266; NP_001186267; NP_001186268; NP_080949
	Wikidata
View/Edit Human	View/Edit Mouse

Apolipoprotein O also known as protein FAM121B is a protein that in humans is encoded by the APOO gene. APOO is a member of the apolipoprotein family.

The human, apolipoprotein O is a 198 amino acids protein that contains a 23 amino acids long signal peptide. The apoprotein is secreted by a microsomal triglyceride transfer protein (MTTP)-dependent mechanism, probably as a VLDL-associated protein that is subsequently transferred to HDL. Apolipoprotein O is the first chondroitine sulphate chain containing apolipoprotein.

Apolipoproteins are proteins that binds to lipids. Members of this family promote cholesterol efflux from macrophage cells. They are present in various lipoprotein complexes, including HDL, LDL and VLDL.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000184831 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000079508 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Lamant M, Smih F, Harmancey R, Philip-Couderc P, Pathak A, Roncalli J, Galinier M, Collet X, Massabuau P, Senard JM, Rouet P (November 2006). "ApoO, a novel apolipoprotein, is an original glycoprotein up-regulated by diabetes in human heart". J. Biol. Chem. 281 (47): 36289–302. doi:10.1074/jbc.M510861200. PMID 16956892.

External links

Human APOO genome location and APOO gene details page in the UCSC Genome Browser.

Apolipoprotein O

References

External links

Further reading