Archain 1

ARCN1
Identifiers
Aliases	ARCN1, COPD, archain 1, SRMMD
External IDs	OMIM: 600820; MGI: 2387591; GeneCards: ARCN1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 5A1U, 5A1V, 5A1W, 5A1X, 5A1Y
Gene location (Human) Chr. Chromosome 11 (human) Band 11q23.3 Start 118,572,390 bp End 118,603,033 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 A5.2 Start 44,652,861 bp End 44,679,142 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in islet of Langerhans stromal cell of endometrium body of pancreas Achilles tendon cardia jejunal mucosa beta cell anterior pituitary corpus epididymis urethra Top expressed in seminal vesicula lacrimal gland parotid gland epithelium of small intestine molar lobe of prostate umbilical cord human fetus dermis gastrula More reference expression data BioGPS n/a
Gene ontology Molecular function RNA binding Cellular component cytosol membrane Golgi membrane COPI-coated vesicle membrane transport vesicle endoplasmic reticulum COPI vesicle coat cytoplasmic vesicle COPI-coated vesicle endoplasmic reticulum membrane cytoplasm Golgi apparatus Biological process retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum cerebellar Purkinje cell layer maturation adult locomotory behavior endoplasmic reticulum to Golgi vesicle-mediated transport Golgi vesicle transport protein transport pigmentation intracellular protein transport vesicle-mediated transport transport Golgi localization Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 372 213827 Ensembl ENSG00000095139 ENSMUSG00000032096 UniProt P48444 Q5XJY5 RefSeq (mRNA) NM_001142281 NM_001655 NM_145985 RefSeq (protein) NP_001135753 NP_001646 NP_666097 Location (UCSC) Chr 11: 118.57 – 118.6 Mb Chr 9: 44.65 – 44.68 Mb PubMed search
Wikidata
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Archain 1 is a protein that in humans is encoded by the ARCN1 gene. Also called coatomer subunit delta, this protein is a component of the coatomer complex, and is involved in the (retrograde) transport of proteins from the Golgi apparatus to the endoplasmic reticulum.

Function

This gene maps in a region, which include the mixed lineage leukemia and Friend leukemia virus integration 1 genes, where multiple disease-associated chromosome translocations occur. It is an intracellular protein. Archain sequences are well conserved among eukaryotes and this protein may play a fundamental role in eukaryotic cell biology. It has similarities to heat shock proteins and clathrin-associated proteins, and may be involved in vesicle structure or vesicle trafficking.

References

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

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