| arylesterase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.1.1.2 | ||||||||
| CAS no. | 9032-73-9 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
The enzyme arylesterase (EC 3.1.1.2) catalyzes the reaction
- a phenyl acetate + H2O a phenol + acetate
This enzyme belongs to the family of hydrolases, specifically those acting on carboxylic ester bonds. The systematic name of this enzyme class is aryl-ester hydrolase. Other names in common use include A-esterase and aromatic esterase. This enzyme participates in bisphenol a degradation.
The activity of arylesterase was, for a time, thought to be the same as aryldialkylphosphatase (EC 3.1.8.1) or merely a special case of it. Indeed, the animal PON enzymes (of the six-blade beta-propeller class) and the archaeal Are enzyme (of the alpha/beta hydrolase class) are documented as exhibiting both activities. The two enzyme Commission numbers share the trivial name of "A-esterase" due to this shared history.
Three human genes code for proteins with this activity: PON1, PON2, PON3.
