Azumolene

Azumolene
Identifiers
  • 1-[(E)-[5-(4-bromophenyl)-1,3-oxazol-2-yl]methylideneamino]imidazolidine-2,4-dione
CAS Number
PubChem CID
ChemSpider
UNII
ChEBI
ChEMBL
CompTox Dashboard (EPA)
Chemical and physical data
FormulaC13H9BrN4O3
Molar mass349.144 g·mol−1
3D model (JSmol)
  • C1C(=O)NC(=O)N1/N=C/C2=NC=C(O2)C3=CC=C(C=C3)Br
  • InChI=1S/C13H9BrN4O3/c14-9-3-1-8(2-4-9)10-5-15-12(21-10)6-16-18-7-11(19)17-13(18)20/h1-6H,7H2,(H,17,19,20)/b16-6+
  • Key:SEGCNGONCZQFDW-OMCISZLKSA-N

Azumolene is an experimental drug which is a derivative of dantrolene. In animal studies, azumolene showed similar efficacy to dantrolene at controlling symptoms of malignant hyperthermia but with better water solubility and lower toxicity, albeit with lower potency.

References

  1. ↑ Sudo RT, Carmo PL, Trachez MM, Zapata-Sudo G (March 2008). "Effects of azumolene on normal and malignant hyperthermia-susceptible skeletal muscle". Basic & Clinical Pharmacology & Toxicology. 102 (3): 308–16. doi:10.1111/j.1742-7843.2007.00156.x. PMID 18047479.
  2. ↑ do Carmo PL, Zapata-Sudo G, Trachez MM, Antunes F, Guimarães SE, Debom R, et al. (2010). "Intravenous administration of azumolene to reverse malignant hyperthermia in swine". Journal of Veterinary Internal Medicine. 24 (5): 1224–8. doi:10.1111/j.1939-1676.2010.0556.x. PMID 20584138.
  3. ↑ Thota S, Rodrigues DA, Pinheiro PS, Lima LM, Fraga CA, Barreiro EJ (September 2018). "N-Acylhydrazones as drugs". Bioorganic & Medicinal Chemistry Letters. 28 (17): 2797–2806. doi:10.1016/j.bmcl.2018.07.015. PMID 30006065. S2CID 51625222.