BMP binding endothelial regulator

BMPER
Identifiers
Aliases	BMPER, CRIM3, CV-2, CV2, BMP binding endothelial regulator
External IDs	OMIM: 608699; MGI: 1920480; GeneCards: BMPER
Gene location (Human)
Chr.	Chromosome 7 (human)
End	34,156,427 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	23,396,496 bp
RNA expression pattern
	Top expressed in
	upper lobe of left lung; ; prefrontal cortex; ; right lung; ; cerebellar hemisphere; ; testicle; ; appendix; ; right hemisphere of cerebellum; ; gonad; ; Brodmann area 9; ; stromal cell of endometrium;
	Top expressed in
	calvaria; ; left lung lobe; ; ureter; ; hand; ; fossa; ; medial ganglionic eminence; ; trigeminal ganglion; ; facial motor nucleus; ; lens; ; otic vesicle;
	More reference expression data
	n/a
Orthologs
Databases	NCBI: entry; OMA: entry
	168667
	73230
	ENSG00000164619
	ENSMUSG00000031963
	Q8N8U9
	Q8CJ69
	NM_133468; NM_001365308
	NM_028472
	NP_597725
	NP_082748
	Wikidata
View/Edit Human	View/Edit Mouse

BMP binding endothelial regulator is a protein that in humans is encoded by the BMPER gene.

Transcription

KLF15 is a strong and direct activator of BMPER expression which is inhibited by SP1. BMPER is inhibited by endothelin-1, which may be mediated by endothelin inhibition of KLF15.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164619 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031963 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: BMP binding endothelial regulator". Retrieved 2011-09-29.
↑ Helbing T, Volkmar F, Goebel U, Heinke J, Diehl P, Pahl HL, Bode C, Patterson C, Moser M (Feb 2010). "Krüppel-like factor 15 regulates BMPER in endothelial cells". Cardiovascular Research. 85 (3): 551–9. doi:10.1093/cvr/cvp314. PMC 4110462. PMID 19767294.

External links

Human BMPER genome location and BMPER gene details page in the UCSC Genome Browser.

Nagase T, Kikuno R, Ohara O (Dec 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
Moser M, Binder O, Wu Y, Aitsebaomo J, Ren R, Bode C, Bautch VL, Conlon FL, Patterson C (Aug 2003). "BMPER, a novel endothelial cell precursor-derived protein, antagonizes bone morphogenetic protein signaling and endothelial cell differentiation". Molecular and Cellular Biology. 23 (16): 5664–79. doi:10.1128/MCB.23.16.5664-5679.2003. PMC 166349. PMID 12897139.
Binnerts ME, Wen X, Canté-Barrett K, Bright J, Chen HT, Asundi V, Sattari P, Tang T, Boyle B, Funk W, Rupp F (Mar 2004). "Human Crossveinless-2 is a novel inhibitor of bone morphogenetic proteins". Biochemical and Biophysical Research Communications. 315 (2): 272–80. doi:10.1016/j.bbrc.2004.01.048. PMID 14766204.
Heinke J, Wehofsits L, Zhou Q, Zoeller C, Baar KM, Helbing T, Laib A, Augustin H, Bode C, Patterson C, Moser M (Oct 2008). "BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis". Circulation Research. 103 (8): 804–12. doi:10.1161/CIRCRESAHA.108.178434. PMID 18787191.
Funari VA, Krakow D, Nevarez L, Chen Z, Funari TL, Vatanavicharn N, Wilcox WR, Rimoin DL, Nelson SF, Cohn DH (Oct 2010). "BMPER mutation in diaphanospondylodysostosis identified by ancestral autozygosity mapping and targeted high-throughput sequencing". American Journal of Human Genetics. 87 (4): 532–7. doi:10.1016/j.ajhg.2010.08.015. PMC 2948790. PMID 20869035.

This article on a gene on human chromosome 7 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164619 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031963 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BMP binding endothelial regulator". Retrieved 2011-09-29.

[pmid19767294-6] Helbing T, Volkmar F, Goebel U, Heinke J, Diehl P, Pahl HL, Bode C, Patterson C, Moser M (Feb 2010). "Krüppel-like factor 15 regulates BMPER in endothelial cells". Cardiovascular Research. 85 (3): 551–9. doi:10.1093/cvr/cvp314. PMC 4110462. PMID 19767294.

BMP binding endothelial regulator

Transcription

References

External links

Further reading