BMS-986224

BMS-986224
Identifiers
  • 3-[5-[(5-chloro-2-pyridinyl)methyl]-1,3,4-oxadiazol-2-yl]-5-(2,6-dimethoxyphenyl)-6-(ethoxymethyl)-4-hydroxy-1H-pyridin-2-one
CAS Number
PubChem CID
UNII
Chemical and physical data
FormulaC24H23ClN4O6
Molar mass498.92 g·mol−1
3D model (JSmol)
  • CCOCC1=C(C(=C(C(=O)N1)C2=NN=C(O2)CC3=NC=C(C=C3)Cl)O)C4=C(C=CC=C4OC)OC
  • InChI=1S/C24H23ClN4O6/c1-4-34-12-15-19(20-16(32-2)6-5-7-17(20)33-3)22(30)21(23(31)27-15)24-29-28-18(35-24)10-14-9-8-13(25)11-26-14/h5-9,11H,4,10,12H2,1-3H3,(H2,27,30,31)
  • Key:AGZKELPIAJYRDT-UHFFFAOYSA-N

BMS-986224 is a drug which is a selective, small-molecule agonist for the apelin receptor. It has been researched for the treatment of heart failure.

See also

References

  1. ↑ Tora G, Jiang J, Bostwick JS, Gargalovic PS, Onorato JM, Luk CE, et al. (October 2021). "Identification of 6-hydroxy-5-phenyl sulfonylpyrimidin-4(1H)-one APJ receptor agonists". Bioorganic & Medicinal Chemistry Letters. 50 128325. doi:10.1016/j.bmcl.2021.128325. PMID 34403724.
  2. ↑ Johnson JA, Kim SH, Jiang J, Phillips M, Schumacher WA, Bostwick JS, et al. (March 2021). "Discovery of a Hydroxypyridinone APJ Receptor Agonist as a Clinical Candidate". Journal of Medicinal Chemistry. 64 (6): 3086–3099. doi:10.1021/acs.jmedchem.0c01878. PMID 33689340.
  3. ↑ Gargalovic P, Wong P, Onorato J, Finlay H, Wang T, Yan M, et al. (March 2021). "In Vitro and In Vivo Evaluation of a Small-Molecule APJ (Apelin Receptor) Agonist, BMS-986224, as a Potential Treatment for Heart Failure". Circulation: Heart Failure. 14 (3) e007351. doi:10.1161/CIRCHEARTFAILURE.120.007351. PMC 7982131. PMID 33663236.