BRAP

BRAP
Identifiers
Aliases	BRAP, BRAP2, IMP, RNF52, BRCA1 associated protein
External IDs	OMIM: 604986; MGI: 1919649; GeneCards: BRAP
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	111,685,956 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	121,825,319 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; secondary oocyte; ; sperm; ; buccal mucosa cell; ; gonad; ; Achilles tendon; ; gastrocnemius muscle; ; islet of Langerhans; ; testicle;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; right kidney; ; zygote; ; lumbar spinal ganglion; ; secondary oocyte; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin protein ligase activity; zinc ion binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; nuclear localization sequence binding; identical protein binding; nucleic acid binding; transferase activity;
Cellular component	cytoplasm; nuclear membrane; ubiquitin ligase complex; cytosol;
Biological process	MAPK cascade; protein ubiquitination; negative regulation of signal transduction; Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8315
	72399
	ENSG00000089234
	ENSMUSG00000029458
	Q7Z569
	Q99MP8
	NM_006768
	NM_001289543; NM_001289544; NM_028227
	NP_006759
	NP_001276472; NP_001276473; NP_082503
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA1 associated protein is a protein that in humans is encoded by the BRAP gene.

Function

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008].

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000089234 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029458 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: BRCA1 associated protein". Retrieved 2018-03-23.

Matheny SA, Chen C, Kortum RL, Razidlo GL, Lewis RE, White MA (January 2004). "Ras regulates assembly of mitogenic signalling complexes through the effector protein IMP". Nature. 427 (6971): 256–60. Bibcode:2004Natur.427..256M. doi:10.1038/nature02237. PMID 14724641. S2CID 4416552.
Asada M, Ohmi K, Delia D, Enosawa S, Suzuki S, Yuo A, Suzuki H, Mizutani S (September 2004). "Brap2 functions as a cytoplasmic retention protein for p21 during monocyte differentiation". Mol. Cell. Biol. 24 (18): 8236–43. doi:10.1128/MCB.24.18.8236-8243.2004. PMC 515069. PMID 15340083.
Chen C, Lewis RE, White MA (May 2008). "IMP modulates KSR1-dependent multivalent complex formation to specify ERK1/2 pathway activation and response thresholds". J. Biol. Chem. 283 (19): 12789–96. doi:10.1074/jbc.M709305200. PMC 2442335. PMID 18332145.
Mallin EA, Pavlicek W (April 2008). "55-year-old woman with menopausal symptoms and a family history of breast cancer". Mayo Clin. Proc. 83 (4): 485–8. doi:10.4065/83.4.485. PMID 18380995.
Czyzyk J, Chen HC, Bottomly K, Flavell RA (August 2008). "p21 Ras/impedes mitogenic signal propagation regulates cytokine production and migration in CD4 T cells". J. Biol. Chem. 283 (34): 23004–15. doi:10.1074/jbc.M804084200. PMC 2516986. PMID 18577512.
Keinan-Boker L, Lerner-Geva L, Kaufman B, Meirow D (October 2008). "Pregnancy-associated breast cancer". Isr. Med. Assoc. J. 10 (10): 722–7. PMID 19009954.
Chen JS, Hu HY, Zhang S, He M, Hu RM (May 2009). "Brap2 facilitates HsCdc14A Lys-63 linked ubiquitin modification". Biotechnol. Lett. 31 (5): 615–21. doi:10.1007/s10529-009-9914-7. PMID 19152073. S2CID 22550914.
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T (March 2009). "SNPs in BRAP associated with risk of myocardial infarction in Asian populations". Nat. Genet. 41 (3): 329–33. doi:10.1038/ng.326. PMID 19198608. S2CID 27136281.
Ozaki K, Sato H, Inoue K, Tsunoda T, Sakata Y, Mizuno H, Lin TH, Miyamoto Y, Aoki A, Onouchi Y, Sheu SH, Ikegawa S, Odashiro K, Nobuyoshi M, Juo SH, Hori M, Nakamura Y, Tanaka T (March 2009). "SNPs in BRAP associated with risk of myocardial infarction in Asian populations". Nat. Genet. 41 (3): 329–33. doi:10.1038/ng.326. PMID 19198608. S2CID 27136281.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000089234 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029458 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: BRCA1 associated protein". Retrieved 2018-03-23.

BRAP

Function

References

Further reading