BRAP

BRAP
Identifiers
Aliases	BRAP, BRAP2, IMP, RNF52, BRCA1 associated protein
External IDs	OMIM: 604986; MGI: 1919649; GeneCards: BRAP
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	111,685,956 bp
Gene location (Mouse)
Chr.	Chromosome 5 (mouse)
End	121,825,319 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; secondary oocyte; ; sperm; ; buccal mucosa cell; ; gonad; ; Achilles tendon; ; gastrocnemius muscle; ; islet of Langerhans; ; testicle;
	Top expressed in
	spermatid; ; spermatocyte; ; seminiferous tubule; ; right kidney; ; zygote; ; lumbar spinal ganglion; ; secondary oocyte; ; lip; ; dentate gyrus of hippocampal formation granule cell; ; left lobe of liver;
	More reference expression data
	n/a
Gene ontology
Molecular function	ubiquitin protein ligase activity; zinc ion binding; metal ion binding; ubiquitin-protein transferase activity; protein binding; nuclear localization sequence binding; identical protein binding; nucleic acid binding; transferase activity;
Cellular component	cytoplasm; nuclear membrane; ubiquitin ligase complex; cytosol;
Biological process	MAPK cascade; protein ubiquitination; negative regulation of signal transduction; Ras protein signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	8315
	72399
	ENSG00000089234
	ENSMUSG00000029458
	Q7Z569
	Q99MP8
	NM_006768
	NM_001289543; NM_001289544; NM_028227
	NP_006759
	NP_001276472; NP_001276473; NP_082503
	Wikidata
View/Edit Human	View/Edit Mouse

BRCA1 associated protein is a protein that in humans is encoded by the BRAP gene.

Function

The protein encoded by this gene was identified by its ability to bind to the nuclear localization signal of BRCA1 and other proteins. It is a cytoplasmic protein which may regulate nuclear targeting by retaining proteins with a nuclear localization signal in the cytoplasm. [provided by RefSeq, Jul 2008].