BRCT domain

BRCA1 C Terminus (BRCT) domain
Structure of an XRCC1 BRCT domain.
Identifiers
SymbolBRCT
PfamPF00533
InterProIPR001357
SCOP21cdz / SCOPe / SUPFAM
CDDcd00027
Available protein structures:
PDB  2azmB:1906-1957 2adoB:1906-1957 2etxA:1906-1957

1kzyC:1795-1835 1l0bA:1589-1669 1t2vC:1646-1723 1n5oX:1646-1723 1t2uA:1646-1723 1jnxX:1646-1723 1t15A:1646-1723 1t29A:1646-1723 1y98A:1646-1723 2couA:91-166 1l7bA:589-664 2cokA:385-463 1wf6A:354-431 1ik9C:681-717 1cdzA:538-616 1oqaA:1756-1842 2coeA:27-111 IPR001357 PF00533 (ECOD; PDBsum)

 
AlphaFold

BRCA1 C Terminus (BRCT) domain is a family of evolutionarily related proteins. It is named after the C-terminal domain of BRCA1, a DNA-repair protein that serves as a marker of breast cancer susceptibility.

The BRCT domain is found predominantly in proteins involved in cell cycle checkpoint functions responsive to DNA damage, for example as found in the breast cancer DNA-repair protein BRCA1. The domain is an approximately 100 amino acid tandem repeat, which appears to act as a phospho-protein binding domain.

Examples

Human proteins containing this domain include:

References

  1. ↑ Zhang X, Moréra S, Bates PA, et al. (November 1998). "Structure of an XRCC1 BRCT domain: a new protein-protein interaction module". EMBO J. 17 (21): 6404–11. doi:10.1093/emboj/17.21.6404. PMC 1170965. PMID 9799248.
  2. ↑ Bork P, Hofmann K, Koonin EV, Bucher P, Neuwald AF, Altschul SF (1997). "A superfamily of conserved domains in DNA damage-responsive cell cycle checkpoint proteins". FASEB J. 11 (1): 68–76. doi:10.1096/fasebj.11.1.9034168. PMID 9034168. S2CID 16457619.
  3. ↑ Yu X, Chini CC, He M, Mer G, Chen J (2003). "The BRCT domain is a phospho-protein binding domain". Science. 302 (5645): 639–642. Bibcode:2003Sci...302..639Y. doi:10.1126/science.1088753. PMID 14576433. S2CID 29407635.
This article incorporates text from the public domain Pfam and InterPro: IPR001357