Beta-phosphoglucomutase

In enzymology, a β-phosphoglucomutase (EC 5.4.2.6) is an enzyme that catalyzes the chemical reaction

β-D-glucose 1-phosphate ${\displaystyle \rightleftharpoons }$ β-D-glucose 6-phosphate

Hence, this enzyme has one substrate, β-D-glucose 1-phosphate, and one product, β-D-glucose 6-phosphate.

This enzyme belongs to the family of isomerases, specifically the phosphotransferases (phosphomutases), which transfer phosphate groups within a molecule. The systematic name of this enzyme class is beta-D-glucose 1,6-phosphomutase. This enzyme participates in starch and sucrose metabolism.

Structural studies

20 structures have been solved for this enzyme PDB. Some of the accession codes are PDB: 1LVH​, PDB: 1O03​, PDB: 1O08​, PDB: 1Z4N​, PDB: 1Z4O​, and PDB: 1ZOL​. Most of these structures detail metal fluoride analogue complexes which are used to mimic different states along the reaction coordinate.

References

• Ben-Zvi R, Schramm M (1961). "A phosphoglucomutase specific for beta-glucose 1-phosphate". J. Biol. Chem. 236 (8): 2186–2189. doi:10.1016/S0021-9258(18)64053-0.
• Boyer PD, ed. (1972). The Enzymes. Vol. 6 (3rd ed.). pp. 407–477.