Mazisotine

Mazisotine
Clinical data
Other namesLY3556050, CNTX-0290
Identifiers
  • (1S,5R)-N-[2-methyl-1-[(3-methyl-2-pyridinyl)oxy]propan-2-yl]-3-azabicyclo[3.1.0]hexane-6-carboxamide
CAS Number
PubChem CID
ChemSpider
UNII
ChEMBL
Chemical and physical data
FormulaC16H23N3O2
Molar mass289.379 g·mol−1
3D model (JSmol)
  • CC(C)(COc1ncccc1C)NC(=O)[C@H]1[C@@H]2CNC[C@H]12
  • InChI=1S/C16H23N3O2/c1-10-5-4-6-18-15(10)21-9-16(2,3)19-14(20)13-11-7-17-8-12(11)13/h4-6,11-13,17H,7-9H2,1-3H3,(H,19,20)/t11-,12+,13?
  • Key:PCINBSQTEDBZDB-FUNVUKJBSA-N

Mazisotine (LY3556050, CNTX-0290) is a chemical compound which acts as an agonist at somatostatin receptor 4. It has analgesic effects and has been researched for the treatment of pain associated with arthritis and neuropathic pain. It was not pursued for human medical use following disappointing results in Phase II clinical trials, but continues to be used in scientific research.

See also

References

  1. ↑ Stevens R, Corradini L, Doods H (April 2019). "Preclinical Evaluation of Human Somatostatin Receptor 4 (hSSTR4) Agonist CNTX-0290 for Mixed Pain Conditions". The Journal of Pain. 20 (4): S73. doi:10.1016/j.jpain.2019.02.092.
  2. ↑ Nguyen TH, Saito T, Chang W, Navarro A, Davies HM (March 2026). "Diastereoselective Cyclopropanation with Secondary Diazoacetamides to Access endo-Azabicyclo[3.1.0]hexane-6-carboxamides". Organic Letters. 28 (9): 3063–3067. doi:10.1021/acs.orglett.6c00392. PMC 12973298. PMID 41729728.