Phenacemide

Phenacemide
Clinical data
Trade names	Phenurone
AHFS/Drugs.com	Micromedex Detailed Consumer Information
ATC code	N03AX07 (WHO) ;
Pharmacokinetic data
Elimination half-life	22–25 hours
Identifiers
	IUPAC name N-Carbamoyl-2-phenyl-acetamide;
CAS Number	63-98-9 ;
PubChem CID	4753;
IUPHAR/BPS	7265;
DrugBank	DB01121 ;
ChemSpider	4589 ;
UNII	PAI7J52V09;
KEGG	D00504 ;
ChEMBL	ChEMBL918 ;
CompTox Dashboard (EPA)	DTXSID6023442 ;
ECHA InfoCard	100.000.519
Chemical and physical data
Formula	C9H10N2O2
Molar mass	178.191 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES O=C(NC(=O)N)Cc1ccccc1;
	InChI InChI=1S/C9H10N2O2/c10-9(13)11-8(12)6-7-4-2-1-3-5-7/h1-5H,6H2,(H3,10,11,12,13) ; Key:XPFRXWCVYUEORT-UHFFFAOYSA-N ;
	(verify)

Phenacemide (INN, BAN) (brand name Phenurone), also known as phenylacetylurea, is an anticonvulsant of the ureide (acetylurea) class. It is a congener and ring-opened analogue of phenytoin (a hydantoin), and is structurally related to the barbiturates and to other hydantoins. Phenacemide was introduced in 1949 for the treatment of epilepsy, but was eventually withdrawn due to toxicity.

References

↑ Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1578–. ISBN 978-0-412-46630-4.
1 2 Prasad JP (2010). "Central Nervous System". Conceptual Pharmacology. Universities Press. pp. 236–. ISBN 978-81-7371-679-9.
1 2 Saxena AK, Saxena M (1995). "Developments in anticonvulsants". In deStevens G, Zingel V, Leschke C, Hoeprich P, Schultz R, Mehrotra P, et al. (eds.). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Vol. 44. Basel: Birkhäuser. pp. 185–291. doi:10.1007/978-3-0348-7161-7_6. ISBN 978-3-0348-7161-7. PMID 7644666. {{cite book}}: |journal= ignored (help)
↑ Kadam SS, Mahadik KR, Bothara KG (1 July 2007). "Central Nervous System Depresants". Principles of Medicinal Chemistry. Vol. II. Pragati Books Pvt. Ltd. pp. 147–. ISBN 978-81-85790-03-9.

External links

Diseases Database (DDB): 34078
MedlinePlus DrugInfo uspdi-202454

This anticonvulsant-related article is a stub. You can help Wikipedia by adding missing information.

[GanellinTriggle1996-1] Ganellin CR, Triggle DJ (21 November 1996). Dictionary of Pharmacological Agents. CRC Press. pp. 1578–. ISBN 978-0-412-46630-4.

[UniversitiesPress2010-2] 1 2 Prasad JP (2010). "Central Nervous System". Conceptual Pharmacology. Universities Press. pp. 236–. ISBN 978-81-7371-679-9.

[deStevensZingel2013-3] 1 2 Saxena AK, Saxena M (1995). "Developments in anticonvulsants". In deStevens G, Zingel V, Leschke C, Hoeprich P, Schultz R, Mehrotra P, et al. (eds.). Progress in Drug Research / Fortschritte der Arzneimittelforschung / Progrès des recherches pharmaceutiques. Vol. 44. Basel: Birkhäuser. pp. 185–291. doi:10.1007/978-3-0348-7161-7_6. ISBN 978-3-0348-7161-7. PMID 7644666. {{cite book}}: |journal= ignored (help)

[Kadam2007-4] Kadam SS, Mahadik KR, Bothara KG (1 July 2007). "Central Nervous System Depresants". Principles of Medicinal Chemistry. Vol. II. Pragati Books Pvt. Ltd. pp. 147–. ISBN 978-81-85790-03-9.

Phenacemide

See also

References

Further reading

External links