Calcitonin gene-related peptide 2

CALCB
Identifiers
Aliases	CALCB, CALC2, CGRP-II, CGRP2, calcitonin related polypeptide beta
External IDs	OMIM: 114160; MGI: 2151253; GeneCards: CALCB
Gene location (Human)
Chr.	Chromosome 11 (human)
End	15,082,342 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	114,235,592 bp
RNA expression pattern
	Top expressed in
	spinal ganglia; ; trigeminal ganglion; ; islet of Langerhans; ; gonad; ; testicle; ; hypothalamus; ; anterior pituitary; ; body of pancreas; ; muscle layer of sigmoid colon; ; retinal pigment epithelium;
	Top expressed in
	facial motor nucleus; ; motor neuron; ; lumbar spinal ganglion; ; anterior horn of spinal cord; ; lactiferous gland; ; trachea; ; trigeminal ganglion; ; embryo; ; embryo; ; vestibular membrane of cochlear duct;
	More reference expression data
	n/a
Gene ontology
Molecular function	neuropeptide hormone activity; hormone activity; calcitonin receptor binding;
Cellular component	extracellular region; extracellular space; intracellular anatomical structure;
Biological process	cellular calcium ion homeostasis; signal transduction; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; adenylate cyclase-activating G protein-coupled receptor signaling pathway; regulation of cytosolic calcium ion concentration;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	797
	12310
	ENSG00000175868
	ENSMUSG00000030669
	P10092
	P70160; Q99JA0
	NM_000728
	NM_001033954; NM_007587; NM_001289444; NM_001305616
	NP_000719
NP_001029126; NP_001276373; NP_001292545; NP_031613; NP_001029126.1;
	NP_001276373.1
	Wikidata
View/Edit Human	View/Edit Mouse

Calcitonin gene-related peptide 2 (CGRP2), also called calcitonin related polypeptide beta, is a hormone that in humans is encoded by the CALCB gene (previously CALC2). Like the related hormone, calcitonin gene-related peptide 1 (CGRP1), this hormone induces vasodilation (relaxation of blood vessels) through the activation of the CGRP receptor. However, this calcitonin gene-related peptide differs from CGRP1 by tissue expression. It is traditionally considered to be the primary form used in the enteric nervous system (nervous system in the gut), whereas CGRP1 is more highly expressed in the central and peripheral nervous system.

The gene that encodes CGRP1, CALCA, also encodes the blood-calcium-reducing hormone calcitonin, but despite its name, CGRP2 is encoded by a distinct gene (CALCB).

Receptors

This hormone activates the CGRP receptor, which is a two protein (heterodimer) complex that is composed of RAMP1 and CALCRL.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000175868 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030669 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "CALCB calcitonin related polypeptide beta". Entrez Gene. NCBI. Retrieved 2026-09-10.
1 2 "Calcitonin gene-related peptide 2". uniprot.org. UniProt consortium. Retrieved 2026-09-20.
↑ "Calcitonin gene-related peptide 1". uniprot.org. UniProt consortium. Retrieved 2026-09-20.
1 2 3 4 Russell FA, King R, Smillie SJ, Kodji X, Brain SD (2014-10-01). "Calcitonin gene-related peptide: physiology and pathophysiology". Physiological reviews. doi:10.1152/physrev.00034.2013. PMC 4187032.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000175868 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030669 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "CALCB calcitonin related polypeptide beta". Entrez Gene. NCBI. Retrieved 2026-09-10.

[uniprot-6] 1 2 "Calcitonin gene-related peptide 2". uniprot.org. UniProt consortium. Retrieved 2026-09-20.

[UniprotCALCA-7] "Calcitonin gene-related peptide 1". uniprot.org. UniProt consortium. Retrieved 2026-09-20.

[Russel2014-8] 1 2 3 4 Russell FA, King R, Smillie SJ, Kodji X, Brain SD (2014-10-01). "Calcitonin gene-related peptide: physiology and pathophysiology". Physiological reviews. doi:10.1152/physrev.00034.2013. PMC 4187032.