CBR3

CBR3
Identifiers
Aliases	CBR3, HEL-S-25, SDR21C2, hcarbonyl reductase 3
External IDs	OMIM: 603608; MGI: 1309992; GeneCards: CBR3
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2HRB
Enzyme activity
Gene location (Human)
Chr.	Chromosome 21 (human)
End	36,146,562 bp
Gene location (Mouse)
Chr.	Chromosome 16 (mouse)
End	93,487,878 bp
RNA expression pattern
	Top expressed in
	gingival epithelium; ; tendon of biceps brachii; ; olfactory zone of nasal mucosa; ; parotid gland; ; cartilage tissue; ; minor salivary glands; ; vulva; ; oral cavity; ; mucosa of pharynx; ; Achilles tendon;
	Top expressed in
	epithelium of stomach; ; pyloric antrum; ; mucous cell of stomach; ; cervix; ; esophagus; ; stroma of bone marrow; ; skin of external ear; ; ankle joint; ; lip; ; dorsal striatum;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	oxidoreductase activity; NADPH binding; carbonyl reductase (NADPH) activity; 3-keto sterol reductase activity; protein binding;
Cellular component	nucleoplasm; extracellular space; cytoplasm; cytosol;
Biological process	phylloquinone catabolic process; cognition; xenobiotic metabolic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	874
	109857
	ENSG00000159231
	ENSMUSG00000022947
	O75828
	Q8K354
	NM_001236
	NM_173047
	NP_001227
	NP_766635
	Wikidata
View/Edit Human	View/Edit Mouse

Carbonyl reductase [NADPH] 3 is an enzyme that in humans is encoded by the CBR3 gene. The enzyme is a member of short chain dehydrogenase/reductase superfamily (SDR).

Carbonyl reductase 3 catalyzes the reduction of a large number of biologically and pharmacologically active carbonyl compounds to their corresponding alcohols. The enzyme is classified as a monomeric NADPH-dependent oxidoreductase. CBR3 contains three exons spanning 11.2 kilobases and is closely linked to another carbonyl reductase gene - CBR1.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000159231 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022947 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Watanabe K, Sugawara C, Ono A, Fukuzumi Y, Itakura S, Yamazaki M, Tashiro H, Osoegawa K, Soeda E, Nomura T (May 1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics. 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676.
↑ Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.
1 2 "Entrez Gene: CBR3 carbonyl reductase 3".

External links

Human CBR3 genome location and CBR3 gene details page in the UCSC Genome Browser.

Wermuth B, Mäder-Heinemann G, Ernst E (1995). "Cloning and expression of carbonyl reductase from rat testis". Eur. J. Biochem. 228 (2): 473–9. doi:10.1111/j.1432-1033.1995.tb20286.x (inactive 21 October 2025). PMID 7705364.{{cite journal}}: CS1 maint: DOI inactive as of October 2025 (link)
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Dahmane N, Ghezala GA, Gosset P, et al. (1998). "Transcriptional map of the 2.5-Mb CBR-ERG region of chromosome 21 involved in Down syndrome". Genomics. 48 (1): 12–23. doi:10.1006/geno.1997.5146. PMID 9503011.
Ismail E, Al-Mulla F, Tsuchida S, et al. (2000). "Carbonyl reductase: a novel metastasis-modulating function". Cancer Res. 60 (5): 1173–6. PMID 10728668.
Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21". Nature. 405 (6784): 311–9. Bibcode:2000Natur.405..311H. doi:10.1038/35012518. PMID 10830953.
Umemoto M, Yokoyama Y, Sato S, et al. (2001). "Carbonyl reductase as a significant predictor of survival and lymph node metastasis in epithelial ovarian cancer". Br. J. Cancer. 85 (7): 1032–6. doi:10.1038/sj.bjc.6692034. PMC 2375107. PMID 11592776.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Lakhman SS, Ghosh D, Blanco JG (2005). "Functional significance of a natural allelic variant of human carbonyl reductase 3 (CBR3)". Drug Metab. Dispos. 33 (2): 254–7. doi:10.1124/dmd.104.002006. PMID 15537833. S2CID 18027092.

This article on a gene on human chromosome 21 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000159231 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022947 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9740676-5] Watanabe K, Sugawara C, Ono A, Fukuzumi Y, Itakura S, Yamazaki M, Tashiro H, Osoegawa K, Soeda E, Nomura T (May 1999). "Mapping of a novel human carbonyl reductase, CBR3, and ribosomal pseudogenes to human chromosome 21q22.2". Genomics. 52 (1): 95–100. doi:10.1006/geno.1998.5380. PMID 9740676.

[pmid19027726-6] Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U (Feb 2009). "The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative". Chem Biol Interact. 178 (1–3): 94–8. Bibcode:2009CBI...178...94P. doi:10.1016/j.cbi.2008.10.040. PMC 2896744. PMID 19027726.

[entrez-7] 1 2 "Entrez Gene: CBR3 carbonyl reductase 3".

v t e Oxidoreductases: alcohol oxidoreductases (EC 1.1)
1.1.1: NAD/NADP acceptor	3-hydroxyacyl-CoA dehydrogenase 3-hydroxybutyryl-CoA dehydrogenase 6-Phosphogluconate dehydrogenase Alcohol dehydrogenase Aldo-keto reductase 1A1 1B1 1B10 1C1 1C3 1C4 7A2 Aldose reductase Beta-Ketoacyl ACP reductase Carbohydrate dehydrogenases Carnitine dehydrogenase D-malate dehydrogenase (decarboxylating) DXP reductoisomerase Glucose-6-phosphate dehydrogenase Glycerol-3-phosphate dehydrogenase HMG-CoA reductase IMP dehydrogenase Isocitrate dehydrogenase Lactate dehydrogenase L-threonine dehydrogenase L-xylulose reductase Malate dehydrogenase Malate dehydrogenase (decarboxylating) Malate dehydrogenase (NADP+) Malate dehydrogenase (oxaloacetate-decarboxylating) Malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) Sorbitol dehydrogenase Hydroxysteroid dehydrogenase: 3β 3β-HSD NSDHL 11β 11β-HSD1 11β-HSD2 17β
1.1.2: cytochrome acceptor	D-lactate dehydrogenase (cytochrome) D-lactate dehydrogenase (cytochrome c-553) Mannitol dehydrogenase (cytochrome)
1.1.3: oxygen acceptor	Alcohol oxidase Glucose oxidase L-gulonolactone oxidase L-lactate oxidase Xanthine oxidase
1.1.4: disulfide as acceptor	Vitamin K epoxide reductase Vitamin-K-epoxide reductase (warfarin-insensitive)
1.1.5: quinone/similar acceptor	Malate dehydrogenase (quinone) Quinoprotein glucose dehydrogenase
1.1.99: other acceptors	Choline dehydrogenase L2HGDH

CBR3

See also

References

External links

Further reading