Protein chibby homolog 1

CBY1
Identifiers
Aliases	CBY1, C22orf2, CBY, HS508I15A, PGEA1, PIGEA-14, PIGEA14, arb1, chibby homolog 1 (Drosophila), chibby family member 1, beta catenin antagonist, Chibby1
External IDs	OMIM: 607757; MGI: 1920989; GeneCards: CBY1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WRQ
Gene location (Human) Chr. Chromosome 22 (human) Band 22q13.1 Start 38,656,636 bp End 38,673,854 bp
Gene location (Mouse) Chr. Chromosome 15 (mouse) Band 15 E1|15 Start 79,543,400 bp End 79,551,861 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in oocyte secondary oocyte right uterine tube tendon of biceps brachii epithelium of bronchus bronchial epithelial cell muscle layer of sigmoid colon apex of heart ventricular zone right auricle of heart Top expressed in spermatocyte interventricular septum ventricular zone medial ganglionic eminence seminiferous tubule neural tube dentate gyrus of hippocampal formation granule cell neural layer of retina visual cortex granulocyte More reference expression data BioGPS More reference expression data
Gene ontology Molecular function beta-catenin binding protein binding identical protein binding protein homodimerization activity Cellular component cytosol trans-Golgi network Golgi apparatus nuclear speck nucleus nucleoplasm cytoplasm centriole cytoskeleton cell projection ciliary basal body Biological process protein localization cardiac muscle cell differentiation negative regulation of Wnt signaling pathway cell differentiation negative regulation of transcription, DNA-templated fat cell differentiation cell projection organization protein homotetramerization cilium assembly ciliary transition zone assembly Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 25776 73739 Ensembl ENSG00000100211 ENSMUSG00000022428 UniProt Q9Y3M2 Q9D1C2 RefSeq (mRNA) NM_015373 NM_001002880 NM_028634 RefSeq (protein) NP_001002880 NP_056188 NP_082910 Location (UCSC) Chr 22: 38.66 – 38.67 Mb Chr 15: 79.54 – 79.55 Mb PubMed search
Wikidata
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Protein chibby homolog 1 is a protein that in humans is encoded by the CBY1 gene.

Function

Beta-catenin is a transcriptional activator and oncoprotein involved in the development of several cancers. The protein encoded by this gene interacts directly with the C-terminal region of beta-catenin, inhibiting oncogenic beta-catenin-mediated transcriptional activation by competing with transcription factors for binding to beta-catenin. Two transcript variants encoding different isoforms have been found for this gene.

Interactions

CBY1 has been shown to interact with Beta-catenin. CBY1 has also been shown to interact with CEP164, CIBAR1 (FAM92A1), and RAB8A.